COMPARING THE EFFECT OF LOW DOSE HMG PLUS METFORMIN AND LOW HMG IN PCOS PATIENTS RESISTANT TO CLOMIPHENE CITRATE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NAZARI T.; HAJI AHMADI M.; ZEYNALZADEH MAHTAB; ESMAELZADEH S.; GHOLIZADEH M.; BALEGHI M.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Reproduction & Infertility Year:2003 | Volume:4 | Issue:2 (14) Page(s): 123-129

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

3,307

Download:

Cites:

Information Journal Paper

Title

COMPARING THE EFFECT OF LOW DOSE HMG PLUS METFORMIN AND LOW HMG IN PCOS PATIENTS RESISTANT TO CLOMIPHENE CITRATE

Author(s)

Keywords

OVULATION INDUCTIONQ3

POLYCYSTIC OVARYQ3

METJORMINQ3

AND HUMAN MENOPAUSAL GENADOTROPIN (HMG)Q3

Abstract

Polycystic ovary syndrome (PCO) is the most common problem among ovarian dysfunctions that accompany infertility and ovulation problem. The prevalence of ovulation dysfunction is reported as high as 40% in general population .the first step in management of PCO is weight reduction and then drug therapy. Clomiphen citrate is the first choice for OVULATION INDUCTION. Considering the resistance of some patients to this the first choice for OVULATION INDUCTION. Considering the resistance of some patients to this drug, other methods have been also employed. This study evaluated whether metformin had beneficial effect in clomiphen resistant patients with polycystic ovarian syndrome in an infertility clinic or not. Thirty-four patients resistant to clomiphene were randomly divided in to 2 groups. One group was treated with metformin plus HMG (group A) and the other with HMG alone (group B).Hormonal assessment and GTT were preformed before administration of 1500 g of in to 2 groups. One group was treated with metformin and GTT were performed before administration of 1500 g of metformin (500 mg three times daily). HMG was injected the next month. The response was assessed by the restoration of follicle growth (16-18mm) and pregnancy rate. The findings were analyzed by T-test and Chi-Square. In the first group we had 2.4±1.9. Adequate follicle response in each patient. In the second group we had 1.3±1.4 adequate follicle responses. For the first group the number of HMG was 6.2±1.4 while for the second group it was 6.1±1. In the first group (P=0.17) the stimulation length was 10.5±1.4 days (P=0.77), and in the second group, it was 10±1.4 days. There was no significant difference in length of stimulation and total HMG received among the two groups. For the first group, the pregnancy rate was 29.4% and in the second groups, the rate appeared to be 11.8% (P=0.199), the difference was not statistically significant. In the first group, there were four patients with hyperinsulinemia, all of them had follicle growth. But in the second group, there were five patients with hyperinsulinemia but only one of them had follicle response. Metformin is not always beneficial when given to clomiphene-resistant infertile women with PCO in clinical practice, We recommend that the use of metfornin in PCO patients with hyperinsulinemia.

Cites

No record.

References

Cite

APA: Copy

NAZARI, T., HAJI AHMADI, M., ZEYNALZADEH, MAHTAB, ESMAELZADEH, S., GHOLIZADEH, M., & BALEGHI, M.. (2003). COMPARING THE EFFECT OF LOW DOSE HMG PLUS METFORMIN AND LOW HMG IN PCOS PATIENTS RESISTANT TO CLOMIPHENE CITRATE. JOURNAL OF REPRODUCTION AND INFERTILITY, 4(2 (14)), 123-129. SID. https://sid.ir/paper/357882/en

Vancouver: Copy

NAZARI T., HAJI AHMADI M., ZEYNALZADEH MAHTAB, ESMAELZADEH S., GHOLIZADEH M., BALEGHI M.. COMPARING THE EFFECT OF LOW DOSE HMG PLUS METFORMIN AND LOW HMG IN PCOS PATIENTS RESISTANT TO CLOMIPHENE CITRATE. JOURNAL OF REPRODUCTION AND INFERTILITY[Internet]. 2003;4(2 (14)):123-129. Available from: https://sid.ir/paper/357882/en

IEEE: Copy

T. NAZARI, M. HAJI AHMADI, MAHTAB ZEYNALZADEH, S. ESMAELZADEH, M. GHOLIZADEH, and M. BALEGHI, “COMPARING THE EFFECT OF LOW DOSE HMG PLUS METFORMIN AND LOW HMG IN PCOS PATIENTS RESISTANT TO CLOMIPHENE CITRATE,” JOURNAL OF REPRODUCTION AND INFERTILITY, vol. 4, no. 2 (14), pp. 123–129, 2003, [Online]. Available: https://sid.ir/paper/357882/en

Related Journal Papers