THE EFFECT OF METHYLPREDNISOLONE ON THE THERAPEUTIC WINDOW OF SYSTEMIC HYPOTHERMIA FOR THE TREATMENT OF EXPERIMENTAL MILD TRAUMATIC SPINAL CORD INJURY IN RAT

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KARAMOUZIAN S.; ESKANDARI HOSSEIN; SAFIZADEH H.; MALEKPOUR AFSHAR R.; ADABI S.; GHOLAM HOSSEINIAN A.

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Journal: Razi Journal of Medical Sciences Year:2009 | Volume:16 | Issue:66 Page(s): 29-35

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Title

THE EFFECT OF METHYLPREDNISOLONE ON THE THERAPEUTIC WINDOW OF SYSTEMIC HYPOTHERMIA FOR THE TREATMENT OF EXPERIMENTAL MILD TRAUMATIC SPINAL CORD INJURY IN RAT

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Keywords

DELAY HYPOTHERMIAQ3

SPINAL CORD INJURYQ2

METHYLPREDNISOLONEQ3

EARLY HYPOTHERMIAQ3

Abstract

Background and Aim: Many studies have shown the neuroprotective effect of systemic hypothermia in the treatment of SPINAL CORD INJURY. But the effect of DELAY HYPOTHERMIA is not known. The goal of this study was to evaluate the effects of METHYLPREDNISOLONE on the therapeutic window of hypothermia treatment following experimental SPINAL CORD INJURY (SCI) by measuring the accumulation of Polymorphonuclear leukocytes(PMN) at the traumatic site.Materials and Methods : In an experimental study, twenty-four Wistar albino rats (260–300 g) were divided in to six groups of four each: A(only laminectomy), B(Trauma; laminectomy + cord injury), C (methylprednisolone; laminectomy + cord injury + METHYLPREDNISOLONE), D(early hypothermia; laminectomy + cord injury + EARLY HYPOTHERMIA), E(late hypothermia; laminectomy + cord injury + late hypothermia), and F(late hypothermia + METHYLPREDNISOLONE; laminectomy + cord injury + late hypothermia +MP). Traumatic SPINAL CORD INJURY (SCI) was induced by using Weight drop method (30 g.cm) on the anesthetized animals at T9 level. Tissue samples from the spinal cord were harvested 7 hours after laminectomy. PMNs counting were performed by light microscope and the data were analyzed using One-way ANOVA.Results: EARLY HYPOTHERMIA and METHYLPREDNISOLONE inhibited PMN accumulation, but late hypothermia (induced 3 hours after trauma) did not show significant effect on PMN count. DELAY HYPOTHERMIA and METHYLPREDNISOLONE decreased the number of PMN, but it seemes that this effect was related to METHYLPREDNISOLONE. Adding METHYLPREDNISOLONE to DELAY HYPOTHERMIA did have significant beneficial effect, but it was not more than "methylprednisolone alone" group.Conclusion: METHYLPREDNISOLONE cannot extend the Therapeutic window of systemic moderate hypothermia for the treatment of experimental mild traumatic SPINAL CORD INJURY in rat.

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APA: Copy

KARAMOUZIAN, S., ESKANDARI, HOSSEIN, SAFIZADEH, H., MALEKPOUR AFSHAR, R., ADABI, S., & GHOLAM HOSSEINIAN, A.. (2009). THE EFFECT OF METHYLPREDNISOLONE ON THE THERAPEUTIC WINDOW OF SYSTEMIC HYPOTHERMIA FOR THE TREATMENT OF EXPERIMENTAL MILD TRAUMATIC SPINAL CORD INJURY IN RAT. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 16(66), 29-35. SID. https://sid.ir/paper/358835/en

Vancouver: Copy

KARAMOUZIAN S., ESKANDARI HOSSEIN, SAFIZADEH H., MALEKPOUR AFSHAR R., ADABI S., GHOLAM HOSSEINIAN A.. THE EFFECT OF METHYLPREDNISOLONE ON THE THERAPEUTIC WINDOW OF SYSTEMIC HYPOTHERMIA FOR THE TREATMENT OF EXPERIMENTAL MILD TRAUMATIC SPINAL CORD INJURY IN RAT. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2009;16(66):29-35. Available from: https://sid.ir/paper/358835/en

IEEE: Copy

S. KARAMOUZIAN, HOSSEIN ESKANDARI, H. SAFIZADEH, R. MALEKPOUR AFSHAR, S. ADABI, and A. GHOLAM HOSSEINIAN, “THE EFFECT OF METHYLPREDNISOLONE ON THE THERAPEUTIC WINDOW OF SYSTEMIC HYPOTHERMIA FOR THE TREATMENT OF EXPERIMENTAL MILD TRAUMATIC SPINAL CORD INJURY IN RAT,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 16, no. 66, pp. 29–35, 2009, [Online]. Available: https://sid.ir/paper/358835/en

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