Effect of letrozole and raloxifene on in vitro human endometrial stromal cells

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Pourheydar Maryam; RASHIDI ZAHRA; KHAZAEI MOZAFAR

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2020 | Volume:23 | Issue:5 Page(s): 26-34

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Title

Effect of letrozole and raloxifene on in vitro human endometrial stromal cells

Author(s)

Pourheydar Maryam | RASHIDI ZAHRA | KHAZAEI MOZAFAR | Issue Writer Certificate

Keywords

EndometriumQ2

LetrozoleQ1

RaloxifeneQ1

Stromal cellsQ2

Abstract

Introduction Letrozole and Raloxifene are used in female reproductive disease. They have special properties and side-effects. This study was performed with aim to compare the in vitro effects of Letrozole and Raloxifene on human endometrial Stromal cells. Methods This experimental study was performed in 2019 on 16 samples of endometrial biopsy of women with normal menstrual cycles in secretory phase. Endometrial biopsies were digested by collagenase type I. Stromal cells were harvested by using serial filtration of cell suspension through cell strainer (70 and 40 µ m) and ficoll layering. The cells were confirmed by immunohistochemical staining for vimentin. The cells of each biopsy were divided into: control and Letrozole, or control and Raloxifene. After 15 day, morphological changes and cell viability were determined. Data were analyzed by one way ANOVA and Tukey test. Results Cell viability in control and Letrozole 0. 1, 1 and 10 µ M concentration was 14. 7, 7. 8, 5. 6 and 4. 2 ×104 cells, respectively. Cell viability in control and Raloxifene 0. 1, 1 and 10 µ M was 21. 8, 12. 9, 9. 1 and 3×104 cells, respectively; the difference was significant (P<0. 05). The morphological changes score of cells were 3. 86, 3. 38, 2. 68 and 2. 08 in control and Letrozole groups, and were 3. 98, 3. 77, 3. 72, 1. 18 in control and Raloxifene; the difference was significant (P<0. 05). The effect of Letrozole and Raloxifene on the bioavailability and morphology of endometrial Stromal cells was different. Conclusion Letrozole and Raloxifene showed anti-proliferative and dose-dependent effects on in vitro human endometrial Stromal cells and Raloxifene effect was more potent than Letrozole.

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APA: Copy

Pourheydar, Maryam, RASHIDI, ZAHRA, & KHAZAEI, MOZAFAR. (2020). Effect of letrozole and raloxifene on in vitro human endometrial stromal cells. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 23(5 ), 26-34. SID. https://sid.ir/paper/359879/en

Vancouver: Copy

Pourheydar Maryam, RASHIDI ZAHRA, KHAZAEI MOZAFAR. Effect of letrozole and raloxifene on in vitro human endometrial stromal cells. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2020;23(5 ):26-34. Available from: https://sid.ir/paper/359879/en

IEEE: Copy

Maryam Pourheydar, ZAHRA RASHIDI, and MOZAFAR KHAZAEI, “Effect of letrozole and raloxifene on in vitro human endometrial stromal cells,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 23, no. 5 , pp. 26–34, 2020, [Online]. Available: https://sid.ir/paper/359879/en

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