Evaluating the effect of recombinant human growth hormone and Gemcitabine on the proliferation and cell cycle progression of Normal lung fibroblast cells

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Mirzaei Fard M.; ARAMVASH A.

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Journal: JOURNAL OF CELL & TISSUE Year:2019 | Volume:9 | Issue:4 Page(s): 321-332

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Title

Evaluating the effect of recombinant human growth hormone and Gemcitabine on the proliferation and cell cycle progression of Normal lung fibroblast cells

Author(s)

Mirzaei Fard M. | ARAMVASH A. | Issue Writer Certificate

Keywords

ProliferationQ1

Cell cycleQ1

Growth hormoneQ1

GemcitabineQ1

Human fibroblastQ1

Abstract

Aim: In this study, the effects of recombinant human Growth hormone and Gemcitabine alone and in combination with each other were investigated on the lung fibroblast cell lines. Material and methods: Human Growth hormone at 10-400 ng/ml and Gemcitabine at 1-100 μ g/ml concentrations were treated with the human lung fibroblast cells and the analysis were performed with MTT assay, propidium iodide staining and scratch assay. Results: Studies of the Cell cycle and MTT assay revealed the effect of Growth hormone on the progression of the Cell cycle and exit of G1 phase and the cell Proliferation, and the inhibitory effects of the Cell cycle and growth process by Gemcitabin compared with the control sample. The results of the scratch test indicated that the Growth hormone at its effective concentrations caused increased the cell migration compared to control, while the Gemcitabin reduced the migration of the cell to the control. Conclusions: Using Growth hormone in combination to gemcitabin during chemotherapy treatment, it seems that we can reduce the rate of the neem normal cells death. Since these cells are more sensitive to Growth hormone´ s effect than cancer cells.

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APA: Copy

Mirzaei Fard, M., & ARAMVASH, A.. (2019). Evaluating the effect of recombinant human growth hormone and Gemcitabine on the proliferation and cell cycle progression of Normal lung fibroblast cells. JOURNAL OF CELL & TISSUE, 9(4 ), 321-332. SID. https://sid.ir/paper/360381/en

Vancouver: Copy

Mirzaei Fard M., ARAMVASH A.. Evaluating the effect of recombinant human growth hormone and Gemcitabine on the proliferation and cell cycle progression of Normal lung fibroblast cells. JOURNAL OF CELL & TISSUE[Internet]. 2019;9(4 ):321-332. Available from: https://sid.ir/paper/360381/en

IEEE: Copy

M. Mirzaei Fard, and A. ARAMVASH, “Evaluating the effect of recombinant human growth hormone and Gemcitabine on the proliferation and cell cycle progression of Normal lung fibroblast cells,” JOURNAL OF CELL & TISSUE, vol. 9, no. 4 , pp. 321–332, 2019, [Online]. Available: https://sid.ir/paper/360381/en

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