REVIEW OF MOLECULAR MECHANISMS UNDERLYING GEMCITABINE RESISTANCE IN PANCREATIC CANCER

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RAJABPOUR A.; TEIMOORI TOOLABI L.; RAJAEI F.

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Journal: Journal of Inflammatory Diseases Year:2017 | Volume:21 | Issue:4 (93) Page(s): 65-77

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Title

REVIEW OF MOLECULAR MECHANISMS UNDERLYING GEMCITABINE RESISTANCE IN PANCREATIC CANCER

Author(s)

RAJABPOUR A. | TEIMOORI TOOLABI L. | RAJAEI F. | Issue Writer Certificate

Keywords

PANCREATIC CANCERQ1

DRUG RESISTANCEQ2

GEMCITABINEQ2

MICRORNASQ2

Abstract

PANCREATIC CANCER is one the most malignant cancers in human. A great percentage of patients die annually due to lack of early detection as well as efficient treatment strategies. Only five-year survival rate is still only seen in 5% of patients. Major problem of this deadly disease is the intrinsic and acquired resistance to current chemotherapeutic agents such as GEMCITABINE. So far, different molecular mechanisms are attributed to GEMCITABINE resistance. For instance, genetic mechanisms, aberrant gene expression in cellular signaling pathways, cancer stem cells, impaired apoptosis related genes, epigenetic changes and potential role of MICRORNAS have been identified in GEMCITABINE resistance of PANCREATIC CANCER. Improving the drug efficacy and overcoming to DRUG RESISTANCE is the current goal in treatment of PANCREATIC CANCER. Understanding the cellular and molecular mechanisms of resistance can help us to develop novel therapeutic approaches leading to increased effectiveness of current treatments. In this review, we summarized the molecular mechanisms involved in GEMCITABINE resistance in PANCREATIC CANCER.

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APA: Copy

RAJABPOUR, A., TEIMOORI TOOLABI, L., & RAJAEI, F.. (2017). REVIEW OF MOLECULAR MECHANISMS UNDERLYING GEMCITABINE RESISTANCE IN PANCREATIC CANCER. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), 21(4 (93) ), 65-77. SID. https://sid.ir/paper/49027/en

Vancouver: Copy

RAJABPOUR A., TEIMOORI TOOLABI L., RAJAEI F.. REVIEW OF MOLECULAR MECHANISMS UNDERLYING GEMCITABINE RESISTANCE IN PANCREATIC CANCER. JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2017;21(4 (93) ):65-77. Available from: https://sid.ir/paper/49027/en

IEEE: Copy

A. RAJABPOUR, L. TEIMOORI TOOLABI, and F. RAJAEI, “REVIEW OF MOLECULAR MECHANISMS UNDERLYING GEMCITABINE RESISTANCE IN PANCREATIC CANCER,” JOURNAL OF INFLAMMATORY DISEASES (THE JOURNAL OF QAZVIN UNIVERSITY OF MEDICAL SCIENCES), vol. 21, no. 4 (93) , pp. 65–77, 2017, [Online]. Available: https://sid.ir/paper/49027/en

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