The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus

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Bahmani Mehrnoush; Peeri Maghsood; AZARBAYJANI MOHAMMAD ALI; MATINHOMAEE HASAN

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Journal: Feyz Medical Sciences Journal Year:2020 | Volume:24 | Issue:2 Page(s): 142-150

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Title

The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus

Author(s)

Bahmani Mehrnoush | Peeri Maghsood | AZARBAYJANI MOHAMMAD ALI | MATINHOMAEE HASAN | Issue Writer Certificate

Keywords

Aerobic continuous exerciseQ1

HIITQ1

Type 2 diabetesQ2

IRS1 geneQ1

Abstract

Background: Physical activity has been recognized, as an effective way to prevent and treat diabetes. This study aimed to determine the effect of the continuous aerobic-versus high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index in liver tissue with type 2 diabetic rats. Materials and Methods: In an experimental study, 24 male Wistar rats aged 6-5 weeks weighed 160 to 180 g. The rats were randomly divided into three groups of 8 controls, aerobic continuity, and severe periodicity. Each group performed their protocol five days a week for eight weeks. 24 hours after the last training session, blood samples were collected directly from heart of rats. The liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data. Results: The results of this research showed that both trainings had a significant effect on the expression of IRS1 gene in the liver of Type 2 diabetes mellitus than in the control group (P=0. 011), but no difference was observed in the two training groups (P=0. 874). There was a significant correlation between IRS1 gene expression and insulin resistance index in the liver of type 2 diabetic rats after a HIIT and continuous exercise (P=-0. 634). Increasing the IRS1 gene, reduced the insulin resistance index (r=-0. 634, P=0. 005). Conclusion: It seems that both intensive and continuous aerobic exercises could be used to improve the indices studied in subjects with Type 2 diabetes.

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APA: Copy

Bahmani, Mehrnoush, Peeri, Maghsood, AZARBAYJANI, MOHAMMAD ALI, & MATINHOMAEE, HASAN. (2020). The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus. FEYZ, 24(2 ), 142-150. SID. https://sid.ir/paper/360498/en

Vancouver: Copy

Bahmani Mehrnoush, Peeri Maghsood, AZARBAYJANI MOHAMMAD ALI, MATINHOMAEE HASAN. The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus. FEYZ[Internet]. 2020;24(2 ):142-150. Available from: https://sid.ir/paper/360498/en

IEEE: Copy

Mehrnoush Bahmani, Maghsood Peeri, MOHAMMAD ALI AZARBAYJANI, and HASAN MATINHOMAEE, “The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus,” FEYZ, vol. 24, no. 2 , pp. 142–150, 2020, [Online]. Available: https://sid.ir/paper/360498/en

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