EVALUATION OF MRNA EXPRESSION PROFILE OF ABCG2/BCRP IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

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ENTEZAR E GHAEM M.; RAHGOZAR S.; MOAFI A.R.; MOSHTAGHIAN J.; ESMAELI A.; ABEDI M.; MONTAZERI F.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2014 | Volume:21 | Issue:5 Page(s): 575-586

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Title

EVALUATION OF MRNA EXPRESSION PROFILE OF ABCG2/BCRP IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA

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Keywords

ABCG2 PROTEINQ2

ALLQ2

MINIMAL RESIDUAL DISEASEQ2

MULTIDRUG RESISTANCEQ2

PROGNOSISQ3

Abstract

Introduction: MULTIDRUG RESISTANCE (MDR) is the main obstacle against treatment of acute lymphoblastic leukemia (ALL). ATP-binding cassette transporters function is mentioned as one of the most effective factors on MDR development. Though, there are many evidences on interference of ABCG2/BCRP, one of the outstanding members of this superfamly, in MDR occurrence, the expression effect of this gene on blasts of ALL patients is unknown yet.Methods: In this study, we used Real-Time PCR technique in order to investigate the relative expression of ABCG2/BCRP mRNA in 1-17 year old children with ALL. Peripheral or bone marrow blood samples from 28 new case leukemic and 15 control children were investigated with cooperation of Seyyedo-Shohada hospital in Isfahan,. MINIMAL RESIDUAL DISEASE (MRD) was evaluated as quality of patient response to chemotherapy.Results: Profile of ABCG2/BCRP mRNA expression did not have any significant difference in new case ALL patients in comparison with control children. On the other hand, comparison of two groups of MRD+ and MRD- patients showed no difference in ABCG2/BCRP expression level. The level of ABCG2 expression was not associated with immunophenotype of ALL or known PROGNOSIS factors for this type of leukemia.Conclusion: Results of this study showed no effect of ABCG2/BCRP expression level on MDR development in ALL. Accordingly, clinical value of ABCG2/BCRP expression profile determination was rejected as the PROGNOSIS value for childhood ALL in our geographical area.

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APA: Copy

ENTEZAR E GHAEM, M., RAHGOZAR, S., MOAFI, A.R., MOSHTAGHIAN, J., ESMAELI, A., ABEDI, M., & MONTAZERI, F.. (2014). EVALUATION OF MRNA EXPRESSION PROFILE OF ABCG2/BCRP IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 21(5), 575-586. SID. https://sid.ir/paper/36062/en

Vancouver: Copy

ENTEZAR E GHAEM M., RAHGOZAR S., MOAFI A.R., MOSHTAGHIAN J., ESMAELI A., ABEDI M., MONTAZERI F.. EVALUATION OF MRNA EXPRESSION PROFILE OF ABCG2/BCRP IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;21(5):575-586. Available from: https://sid.ir/paper/36062/en

IEEE: Copy

M. ENTEZAR E GHAEM, S. RAHGOZAR, A.R. MOAFI, J. MOSHTAGHIAN, A. ESMAELI, M. ABEDI, and F. MONTAZERI, “EVALUATION OF MRNA EXPRESSION PROFILE OF ABCG2/BCRP IN CHILDHOOD ACUTE LYMPHOBLASTIC LEUKEMIA,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 5, pp. 575–586, 2014, [Online]. Available: https://sid.ir/paper/36062/en

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