Evaluation of Bcl2/BAX genes expression ratio as a marker of inflammatory bowel disease

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Javadinia Fariba; KHAZAEI KOOHPAR ZEINAB; ASADZADEH AGHDAEI HAMID

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Journal: Feyz Medical Sciences Journal Year:2019 | Volume:23 | Issue:2 Page(s): 153-157

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Title

Evaluation of Bcl2/BAX genes expression ratio as a marker of inflammatory bowel disease

Author(s)

Javadinia Fariba | KHAZAEI KOOHPAR ZEINAB | ASADZADEH AGHDAEI HAMID | Issue Writer Certificate

Keywords

ApoptosisQ1

BAXQ1

Bcl2Q1

Inflammatory bowel diseaseQ2

Abstract

Background: Apoptosis is an essential physiological process to maintain immune homeostasis. T-cell incorrect Apoptosis appears to be involved in chronic inflammatory diseases such as Inflammatory bowel disease (IBD). The aim of this study was to evaluate the Bcl2/BAX genes expression ratio in patients with IBD (Crohn’ s disease and ulcerative colitis) compared to healthy persons. Materials and Methods: This case-control study was conducted on 49 patients with IBD and 20 healthy subjects. Blood samples were collected from the patients and healthy subjects after receiving complete information and obtaining consent. Then, white blood cells were isolated by the Salting Out technique. After RNA extraction and cDNA synthesis, the Bcl2/BAX expression level was quantitatively measured by the real-time PCR method in the patients and healthy subjects. Results: The results showed that the Bcl2/BAX genes expression ratio in peripheral blood Tcells was not significantly different in patients with IBD compared to the healthy subjects (P=0. 06). Conclusion: It seems that change is not evident in Bcl2/BAX genes expression ratio in peripheral blood T-cells in the patients with IBD.

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APA: Copy

Javadinia, Fariba, KHAZAEI KOOHPAR, ZEINAB, & ASADZADEH AGHDAEI, HAMID. (2019). Evaluation of Bcl2/BAX genes expression ratio as a marker of inflammatory bowel disease. FEYZ, 23(2 ), 153-157. SID. https://sid.ir/paper/360971/en

Vancouver: Copy

Javadinia Fariba, KHAZAEI KOOHPAR ZEINAB, ASADZADEH AGHDAEI HAMID. Evaluation of Bcl2/BAX genes expression ratio as a marker of inflammatory bowel disease. FEYZ[Internet]. 2019;23(2 ):153-157. Available from: https://sid.ir/paper/360971/en

IEEE: Copy

Fariba Javadinia, ZEINAB KHAZAEI KOOHPAR, and HAMID ASADZADEH AGHDAEI, “Evaluation of Bcl2/BAX genes expression ratio as a marker of inflammatory bowel disease,” FEYZ, vol. 23, no. 2 , pp. 153–157, 2019, [Online]. Available: https://sid.ir/paper/360971/en

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