Evaluation of Inhibitory Effects of heat-killed Lactobacillus casei and Lactobacillus paracasei on human chronic myelocytic leukemia K562 cell line: an in vitro study

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RIKI MALIHEH; TUKMECHI AMIR; Haji rahimi Akram; BONYADI FARZANEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:1 Page(s): 1-9

Download Full-Text

Persian Verion

View:

524

Download:

Cites:

Information Journal Paper

Title

Evaluation of Inhibitory Effects of heat-killed Lactobacillus casei and Lactobacillus paracasei on human chronic myelocytic leukemia K562 cell line: an in vitro study

Author(s)

RIKI MALIHEH | TUKMECHI AMIR | Haji rahimi Akram | BONYADI FARZANEH | Issue Writer Certificate

Keywords

K562Q1

ProbioticQ2

anti tumeric propertiesQ1

apoptosisQ1

Abstract

Background: Probiotics are defined as different microorganisms that may have positive effects on preventing or treatment of special pathologic conditions. Anti-cancer properties of these bacteria have been shown in few studies. The aim of this study was to evaluate anti-tumor effects of heat-killed L. casei and L. paracasei on K562 cell line (chronic myeloid leukemia). Methods: In this experimental study, bacteria were cultured in special medium at anaerobic condition, then, cells killed at temperature of 100° C. Killed cells were dried by lyophilization, finally were sterilized by autoclaving. Then, different concentrations of heat-killed bacteria (125, 250, 500, 1000 and 2000 μ g/ml) were prepared separately. Anti-tumor properties of heat-killed bacteria were determined in vitro at 24, 48 and 72 h with MTT assay. Results: Our result showed that heat-killed cells of L. casei and L. paracasei statistically (p˂ 0. 05) have Anti-tumor properties in K562. In addition, Anti-tumor properties of heat-killed cells have direct relationship with concentration. Conclusion: Based on obtained results we conclude that the heat killed Lactobacillus can be used as a potential candidate for further studies on chronic myeloid leukemia treatmentces.

Cites

No record.

References

No record.

Cite

APA: Copy

RIKI, MALIHEH, TUKMECHI, AMIR, Haji rahimi, Akram, & BONYADI, FARZANEH. (2019). Evaluation of Inhibitory Effects of heat-killed Lactobacillus casei and Lactobacillus paracasei on human chronic myelocytic leukemia K562 cell line: an in vitro study. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(1 ), 1-9. SID. https://sid.ir/paper/361005/en

Vancouver: Copy

RIKI MALIHEH, TUKMECHI AMIR, Haji rahimi Akram, BONYADI FARZANEH. Evaluation of Inhibitory Effects of heat-killed Lactobacillus casei and Lactobacillus paracasei on human chronic myelocytic leukemia K562 cell line: an in vitro study. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(1 ):1-9. Available from: https://sid.ir/paper/361005/en

IEEE: Copy

MALIHEH RIKI, AMIR TUKMECHI, Akram Haji rahimi, and FARZANEH BONYADI, “Evaluation of Inhibitory Effects of heat-killed Lactobacillus casei and Lactobacillus paracasei on human chronic myelocytic leukemia K562 cell line: an in vitro study,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 1 , pp. 1–9, 2019, [Online]. Available: https://sid.ir/paper/361005/en

Related Journal Papers