The Effect of Eight Weeks of Increased Aerobic Exercise with Zinc Supplementation on Muscle Superoxide Dismutase Activity and Serum Leptin Levels and Weight Changes in Adult Wistar Rats

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Qasemnia A.; Zighami Z.; HADI S.

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Journal: Armaghane Danesh Year:2020 | Volume:24 | Issue:6 (137) Page(s): 1054-1072

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Title

The Effect of Eight Weeks of Increased Aerobic Exercise with Zinc Supplementation on Muscle Superoxide Dismutase Activity and Serum Leptin Levels and Weight Changes in Adult Wistar Rats

Author(s)

Qasemnia A. | Zighami Z. | HADI S. | Issue Writer Certificate

Keywords

aerobic exerciseQ1

Zinc supplementationQ2

Superoxide dismutaseQ2

LeptinQ2

Male ratQ2

Abstract

Background & aim: Intense and prolonged exercise and physical activity are the factors that can disrupt the balance of free radical production, antioxidant systems of the body and decreased Leptin levels. It has also been suggested that zinc acts as a mediator in Leptin production while affecting Superoxide dismutase activation and food intake. The purpose of the present study was to determine and evaluate the effect of 8 weeks of incremental aerobic training with Zinc supplementation on muscle Superoxide dismutase activity, serum Leptin level and weight changes in male Wistar rats. Methods: In the present experimental study, 32 male Wistar rats were randomly divided into 4 equal groups (control, exercise, exercise + zinc and zinc). The training protocol consisted of incremental aerobic exercise on the treadmill for 8 weeks (5 days a week). In the zinc supplement group, 227 mg of zinc sulfate was dissolved in 100 ml of edible water and made available to the animals. 48 hours after the last training session, blood and tissue samples were collected and Leptin concentration and the amount of Superoxide dismutase activity was measured by ELISA and spectrophotometrically respectively. Data were analyzed using one-way ANOVA and Pearson correlation tests. Results: no significant difference was observed after eight weeks of training with Zinc supplementation in skeletal muscle Superoxide dismutase activity among groups (p<0. 05), but serum Leptin and weight changes in the groups Zinc supplementation and exercise group consumed significantly less Zinc supplementation than the control group (p<0. 05) In the control group (P=0. 04, R=0. 71) and in the exercise group (P=0. 03, R=0. 75), there was an inverse correlation was observed between serum Leptin level and muscle Superoxide dismutase activity. Conclusion: according to the results of the present study, it was concluded that Zinc supplementation has been shown to control weight, decrease Leptin and reverse the correlation between serum Leptin and Superoxide dismutase activity.

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References

THE EFFECT OF THREE MONTHS OF ZINC-MAGNESIUM SUPPLEMENTATION ALONG WITH INTENSE ENDURANCE TRAINING ON SOMATOMEDIN C AND ENDURANCE PERFORMANCE IN MATURE FEMALE RATS

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APA: Copy

Qasemnia, A., Zighami, Z., & HADI, S.. (2020). The Effect of Eight Weeks of Increased Aerobic Exercise with Zinc Supplementation on Muscle Superoxide Dismutase Activity and Serum Leptin Levels and Weight Changes in Adult Wistar Rats. ARMAGHAN DANESH, 24(6 (137) ), 1054-1072. SID. https://sid.ir/paper/361033/en

Vancouver: Copy

Qasemnia A., Zighami Z., HADI S.. The Effect of Eight Weeks of Increased Aerobic Exercise with Zinc Supplementation on Muscle Superoxide Dismutase Activity and Serum Leptin Levels and Weight Changes in Adult Wistar Rats. ARMAGHAN DANESH[Internet]. 2020;24(6 (137) ):1054-1072. Available from: https://sid.ir/paper/361033/en

IEEE: Copy

A. Qasemnia, Z. Zighami, and S. HADI, “The Effect of Eight Weeks of Increased Aerobic Exercise with Zinc Supplementation on Muscle Superoxide Dismutase Activity and Serum Leptin Levels and Weight Changes in Adult Wistar Rats,” ARMAGHAN DANESH, vol. 24, no. 6 (137) , pp. 1054–1072, 2020, [Online]. Available: https://sid.ir/paper/361033/en

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