Dietary supplementation with Salvia officinalis L. and aerobic training attenuates memory deficits via the CREB-BDNF pathway in amyloid beta-injected rats

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MOHSENI IMAN; PEERI MAGHSOUD; AZARBAYJANI MOHAMAD ALI

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Journal: Journal of Medicinal Plants Year:2020 | Volume:19 | Issue:73 Page(s): 119-132

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Information Journal Paper

Title

Dietary supplementation with Salvia officinalis L. and aerobic training attenuates memory deficits via the CREB-BDNF pathway in amyloid beta-injected rats

Author(s)

MOHSENI IMAN | PEERI MAGHSOUD | AZARBAYJANI MOHAMAD ALI | Issue Writer Certificate

Keywords

Salvia officinalis L.Q2

Alzheimer’s diseaseQ1

HippocampusQ2

TreadmillQ3

Abstract

Background: AD is a neurodegenerative disorder in which there is a gathering of beta-amyloid plaques, primarily in the Hippocampus, that lead to neuronal death. Exercise training and botanical medications can play a role in the prevention and treatment of neurodegenerative disorders. Objective: The aim of this study was to determine the effects of aerobic training and Salvia officinalis extract on the improvement of learning and memory deficits in amyloid beta-injected rats. Methods: Rats were injected with an Aβ solution into the CA1 hippocampal region. Rats were then exposed to Treadmill exercise and S. officinalis extract for 4 weeks, at which point they performed the MWM. Additionally, we studied the molecular factors involved in neuronal plasticity, such as CREB and BDNF. The animals were also evaluated histologically to determine the deposition of Aβ in the brain tissue. Results: The results showed that aerobic training and S. officinalis improved learning and memory in the behavioral test. The results of the molecular analysis showed that CREB and BDNF levels were attenuated in the Aβ-injected rats in comparison with the control group. The density of surviving neurons was considerably higher in the training-extract-Aβ group (P<0. 01) and extract-Aβ group (P<0. 05) than the negative control groups. Conclusion: In the present study, behavioral testing and biochemical analysis demonstrated that aerobic training and S. officinalis extract treatment for 4 weeks protects against memory deficits in Aβ-injected rats.

Cites

Anti-amyloidogenic and disaggregating effects of Salvia officinalis in vitro: a strategy to reduce the insulin amyloid fibrils due to repeated subcutaneous injections in diabetic patients

References

7, 8-dihydroxyflavone facilitates the action exercise to restore plasticity and functionality: Implications for early brain trauma recovery

Cite

APA: Copy

MOHSENI, IMAN, PEERI, MAGHSOUD, & AZARBAYJANI, MOHAMAD ALI. (2020). Dietary supplementation with Salvia officinalis L. and aerobic training attenuates memory deficits via the CREB-BDNF pathway in amyloid beta-injected rats. JOURNAL OF MEDICINAL PLANTS, 19(73 ), 119-132. SID. https://sid.ir/paper/361492/en

Vancouver: Copy

MOHSENI IMAN, PEERI MAGHSOUD, AZARBAYJANI MOHAMAD ALI. Dietary supplementation with Salvia officinalis L. and aerobic training attenuates memory deficits via the CREB-BDNF pathway in amyloid beta-injected rats. JOURNAL OF MEDICINAL PLANTS[Internet]. 2020;19(73 ):119-132. Available from: https://sid.ir/paper/361492/en

IEEE: Copy

IMAN MOHSENI, MAGHSOUD PEERI, and MOHAMAD ALI AZARBAYJANI, “Dietary supplementation with Salvia officinalis L. and aerobic training attenuates memory deficits via the CREB-BDNF pathway in amyloid beta-injected rats,” JOURNAL OF MEDICINAL PLANTS, vol. 19, no. 73 , pp. 119–132, 2020, [Online]. Available: https://sid.ir/paper/361492/en

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