Evaluation of Antidiabtic and hepatoprotective effects of aquatic extract of Stevia rebaudiana leaves (sweet fraction) in streptozotocin-induced diabetic mice

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Zangeneh Mohammad Mahdi; GOODARZI NADER; Zangeneh Akram

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:4 Page(s): 319-329

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Title

Evaluation of Antidiabtic and hepatoprotective effects of aquatic extract of Stevia rebaudiana leaves (sweet fraction) in streptozotocin-induced diabetic mice

Author(s)

Zangeneh Mohammad Mahdi | GOODARZI NADER | Zangeneh Akram | Issue Writer Certificate

Keywords

Stevia rebaudianaQ1

StreptozotocinQ2

DiabetesQ2

LiverQ2

MiceQ2

Abstract

Introdution: Stevia rebaudiana has been recently known as an antioxidant, anti-inflammatory, and antimicrobial agent. Hepatoprotective and antidiabetic properties of the aquatic extract of Stevia. rebaudiana on diabetic male Mice have been assessed in the present study. Methods: In this experimental study, Diabetes was induced by administration of 60 mg/kg of Streptozotocin intraperitoneally in 28 mature male Mice and they were randomly divided into 4 groups. One group considered as non-diabetic negative control. The non-diabetic and diabetic negative control groups received normal saline and the treatment groups received glibenclamide at dose 0. 5 mg/kg and aquatic extract of Stevia rebaudiana at doses of 200 and 400 μ g/kg through gavage for 15 consecutive days. On the last day, serum levels of blood glucose and AST (aspartate aminotransferase), ALT (alanineaminotransferase), and ALP (alkaline-phosphatase) enzymes were measured. Structural changes of the Liver tissue was assessed stereologically. The data were analyzed by one way variance analysis and Duncan’ s test using SPSS 21. Results: The levels of blood glucose and ALT and ALP enzymes were decreased significantly (P <0. 05) in aquatic extract-treated groups as compared to the positive control group. The total volume of Liver, hepatocytes, sinusoids, central vein, and hepatic artery decreased significantly (P <0. 05) after treatment with high dose of Stevia rebaudiana aquatic extract. Conclusion: It seems that the Stevia rubadiana sweet extract can prevent hepatic tissue damage in diabetic Mice by regulating serum glucose levels and Liver enzymes.

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APA: Copy

Zangeneh, Mohammad Mahdi, GOODARZI, NADER, & Zangeneh, Akram. (2018). Evaluation of Antidiabtic and hepatoprotective effects of aquatic extract of Stevia rebaudiana leaves (sweet fraction) in streptozotocin-induced diabetic mice. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(4 ), 319-329. SID. https://sid.ir/paper/36191/en

Vancouver: Copy

Zangeneh Mohammad Mahdi, GOODARZI NADER, Zangeneh Akram. Evaluation of Antidiabtic and hepatoprotective effects of aquatic extract of Stevia rebaudiana leaves (sweet fraction) in streptozotocin-induced diabetic mice. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(4 ):319-329. Available from: https://sid.ir/paper/36191/en

IEEE: Copy

Mohammad Mahdi Zangeneh, NADER GOODARZI, and Akram Zangeneh, “Evaluation of Antidiabtic and hepatoprotective effects of aquatic extract of Stevia rebaudiana leaves (sweet fraction) in streptozotocin-induced diabetic mice,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 4 , pp. 319–329, 2018, [Online]. Available: https://sid.ir/paper/36191/en

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