EFFECT OF N-ACETYLCYSTEINE IN PROTECTING FROM SIMULTANEOUS NOISE AND CARBON MONOXIDE INDUCED HAIR CELL LOSS

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POURBAKHT AKRAM

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Journal: Auditory and Vestibular Research Journal Year:2011 | Volume:20 | Issue:1 (35) Page(s): 107-115

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Title

EFFECT OF N-ACETYLCYSTEINE IN PROTECTING FROM SIMULTANEOUS NOISE AND CARBON MONOXIDE INDUCED HAIR CELL LOSS

Author(s)

POURBAKHT AKRAM | Issue Writer Certificate

Keywords

N-ACETYLCYSTEINEQ2

NOISE-INDUCED HEARING LOSSQ2

CARBON MONOXIDEQ2

HAIR CELLQ2

HISTOLOGYQ2

Abstract

Background and Aim: N-ACETYLCYSTEINE, a glutathione precursor and reactive oxygen species scavenger, is reported to be effective in reducing NOISE-INDUCED HEARING LOSS. Many workers in industry are exposed simultaneously to noise and chemical pollutants such as CARBON MONOXIDE. We investigated effectiveness of N-ACETYLCYSTEINE in protecting the cochlea from simultaneous noise and CARBON MONOXIDE damages.Methods: Twelve rabbits were exposed simeltaneously to 100 dB sound pressure level of broad band noise and CARBON MONOXIDE 8 hours a day for 5 days.One hour before exposure, experimental group received 325 mg/kg of N-ACETYLCYSTEINE while normal saline was administered for the control group.The protective effect of N-ACETYLCYSTEINE was evaluated 3 weeks after exposure by histological assessment of the HAIR CELLs.Results: Simultaneous exposure to noise and CARBON MONOXIDE resulted in a considerable damage to the outer HAIR CELLs; however, the inner HAIR CELLs and the pillar cells remained intact. Use of Nacetylcysteine in the experimental group significantly reduced the extent of outer HAIR CELL loss.Conclusion: N-ACETYLCYSTEINE attenuates simultaneous noise and CARBON MONOXIDE induced HAIR CELL damage in rabbits.

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APA: Copy

POURBAKHT, AKRAM. (2011). EFFECT OF N-ACETYLCYSTEINE IN PROTECTING FROM SIMULTANEOUS NOISE AND CARBON MONOXIDE INDUCED HAIR CELL LOSS. AUDITORY AND VESTIBULAR RESEARCH, 20(1 (35)), 107-115. SID. https://sid.ir/paper/362069/en

Vancouver: Copy

POURBAKHT AKRAM. EFFECT OF N-ACETYLCYSTEINE IN PROTECTING FROM SIMULTANEOUS NOISE AND CARBON MONOXIDE INDUCED HAIR CELL LOSS. AUDITORY AND VESTIBULAR RESEARCH[Internet]. 2011;20(1 (35)):107-115. Available from: https://sid.ir/paper/362069/en

IEEE: Copy

AKRAM POURBAKHT, “EFFECT OF N-ACETYLCYSTEINE IN PROTECTING FROM SIMULTANEOUS NOISE AND CARBON MONOXIDE INDUCED HAIR CELL LOSS,” AUDITORY AND VESTIBULAR RESEARCH, vol. 20, no. 1 (35), pp. 107–115, 2011, [Online]. Available: https://sid.ir/paper/362069/en

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