Effect of Donepezil on Cognitive Disorders Due to the Selective Serotonin Reuptake Inhibitors in the Patients with Major Depressive Disorder

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HOSSEINI FATEMEH; NADI MOHAMMAD; KIANI MINA; Shahzeidi Saeid

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Title

Effect of Donepezil on Cognitive Disorders Due to the Selective Serotonin Reuptake Inhibitors in the Patients with Major Depressive Disorder

Author(s)

HOSSEINI FATEMEH | NADI MOHAMMAD | KIANI MINA | Shahzeidi Saeid | Issue Writer Certificate

Keywords

Cognitive disorderQ1

Depression disorderQ2

DonepezilQ2

Selective serotonin reuptake inhibitor drugsQ1

Montreal conitive testQ1

Abstract

Introduction: Many factors cause cognitive impairment, including medication, such as selective serotonine reuptake inhibitor drugs use. On the other hand, many drugs are used in cognitive impairment therapy, including Donepezil, which act by inhibiting the cholinesterase enzyme and increase brain acetylcholine. Methods: This study was a double-blind controlled randomized controlled clinical trial on the 73 numbers of 20-50 years-old patients treated with selective serotonine reuptake inhibitor drugs using Montreal Cognitive Assessment Test. They were randomly divided into two groups: placebo recipient and Donepezil recipient. The Montreal Cognitive Test-reliability 92% and IC 83%-was performed two months after drug administration in both groups. The results were analyzed by Mann-Whitney, Chi-Square, T-test and has been reviewed by SPSS Inc., Chicago, IL; Version 16. Results: There was a significant difference in the Montreal Cognitive Test score before and after the intervention in the Donepezil group as the score increased. (Paired-T Test & P-Value < 0. 0001). There was also a significant difference in Montreal Cognitive Test scores before and after the intervention in the placebo group (Paired-T Test & P-Value < 0. 0001) as the score dropped. Conclusion: Cholinesterase inhibitors, such as Donepezil, have had beneficial effects in improving cognitive impairment caused by Selective serotonin reuptake inhibitor drugs compared to placebo.

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APA: Copy

HOSSEINI, FATEMEH, NADI, MOHAMMAD, KIANI, MINA, & Shahzeidi, Saeid. (2020). Effect of Donepezil on Cognitive Disorders Due to the Selective Serotonin Reuptake Inhibitors in the Patients with Major Depressive Disorder. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 27(10 ), 2017-2026. SID. https://sid.ir/paper/36243/en

Vancouver: Copy

HOSSEINI FATEMEH, NADI MOHAMMAD, KIANI MINA, Shahzeidi Saeid. Effect of Donepezil on Cognitive Disorders Due to the Selective Serotonin Reuptake Inhibitors in the Patients with Major Depressive Disorder. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;27(10 ):2017-2026. Available from: https://sid.ir/paper/36243/en

IEEE: Copy

FATEMEH HOSSEINI, MOHAMMAD NADI, MINA KIANI, and Saeid Shahzeidi, “Effect of Donepezil on Cognitive Disorders Due to the Selective Serotonin Reuptake Inhibitors in the Patients with Major Depressive Disorder,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 10 , pp. 2017–2026, 2020, [Online]. Available: https://sid.ir/paper/36243/en

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