Effects of hydroalcoholic extract of Glycyrrhiza glabra and glycyrrhizic acid on promastigote and amastigote of Leishmania major (MRHO/IR/75/ER)

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Sheikhi Shima; KHAMESIPOUR ALI; Radjabian Tayebeh; Mojallal Tabatabaei Zahra; GHAZANFARI TOOBA

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Journal: Journal of Medicinal Plants Year:2020 | Volume:19 | Issue:74 Page(s): 73-83

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Title

Effects of hydroalcoholic extract of Glycyrrhiza glabra and glycyrrhizic acid on promastigote and amastigote of Leishmania major (MRHO/IR/75/ER)

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Keywords

Glycyrrhiza glabraQ2

Glycyrrhizic acidQ1

In vitroQ1

Leishmania majorQ1

PromastigoteQ2

AmastigoteQ1

Abstract

Background: Cutaneous leishmaniasis by different species of Leishmania. Pentavalen antimonials as a first line drug for treatment of cutaneous leishmaniasis have several limitations and side effects. Natural products are more considered due to their less toxicity and cost, more efficient, safety and readily available antileishmania agents. Objective: The aim of this study was to explore the effect of hydroalcoholic extract of Glycyrrhiza glabra (licorice) roots and its main component Glycyrrhizic acid on Promastigote and Amastigote of L. major. Methods: Different dosages of hydroalcoholic extract of licorice root, Glycyrrhizic acid and Glucantime with Promastigote of L. major were incubated at 26 ° C for 24 and 48 hours then the percentages of alive Promastigotes were measured by MTT assay. The antiAmastigote effects of these drugs was examined by microscopic counting of the number of Amastigotes in macrophages 24 hours after treating the parasite infected macrophages with them. Promastigote and infected macrophages without any treatment was used as negative controls. Results: The IC50 values of hydroalcoholic extracts of licorice root, Glycyrrhizic acid and Glucantime on Promastigote of L. major was 1250 ± 0. 018, 3000 ± 0. 017 and 50 ± 0. 043 μ g/ml after 24 hours, and 1000 ± 0. 016, 3000 ± 0. 017 and 25 ± 0. 009 μ g/ml after 48 hours, respectively. The IC50 values of the licorice root extract, Glycyrrhizic acid and Glucantime on amostigate was 500, 1000 and 25 μ g/ml, respectively. Conclusion: Hydroalcoholic extract of licorice root and Glycyrrhizic acid had cytotoxic effects on Promastigotes and Amastigotes of L. major.

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APA: Copy

Sheikhi, Shima, KHAMESIPOUR, ALI, Radjabian, Tayebeh, Mojallal Tabatabaei, Zahra, & GHAZANFARI, TOOBA. (2020). Effects of hydroalcoholic extract of Glycyrrhiza glabra and glycyrrhizic acid on promastigote and amastigote of Leishmania major (MRHO/IR/75/ER). JOURNAL OF MEDICINAL PLANTS, 19(74 ), 73-83. SID. https://sid.ir/paper/362910/en

Vancouver: Copy

Sheikhi Shima, KHAMESIPOUR ALI, Radjabian Tayebeh, Mojallal Tabatabaei Zahra, GHAZANFARI TOOBA. Effects of hydroalcoholic extract of Glycyrrhiza glabra and glycyrrhizic acid on promastigote and amastigote of Leishmania major (MRHO/IR/75/ER). JOURNAL OF MEDICINAL PLANTS[Internet]. 2020;19(74 ):73-83. Available from: https://sid.ir/paper/362910/en

IEEE: Copy

Shima Sheikhi, ALI KHAMESIPOUR, Tayebeh Radjabian, Zahra Mojallal Tabatabaei, and TOOBA GHAZANFARI, “Effects of hydroalcoholic extract of Glycyrrhiza glabra and glycyrrhizic acid on promastigote and amastigote of Leishmania major (MRHO/IR/75/ER),” JOURNAL OF MEDICINAL PLANTS, vol. 19, no. 74 , pp. 73–83, 2020, [Online]. Available: https://sid.ir/paper/362910/en

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