Experimental study: experimental evaluation of phospholipid system containing doxorubicin HCL for use in chemotherapy

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Moosavizadeh Seyed Mohammad; Baghiani Morteza; Majdizadeh Mohammad; HAGHIRALSADAT BIBI FATEMEH; Moosavi zadeh Seyed Mohamoud

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:26 | Issue:11 Page(s): 945-956

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Title

Experimental study: experimental evaluation of phospholipid system containing doxorubicin HCL for use in chemotherapy

Author(s)

Keywords

Drug CarriersQ1

LiposomeQ2

DoxorubicinQ1

Anti-cancerQ2

Drug LiberationQ1

Abstract

Introdution: Common cancer treatment methods have many side effects. Therefore, the use of new methods for drug delivery to cancer cells is necessary. In the present study, nano formulations of lipid carriers containing Doxorubicin have been synthesized and its physicochemical properties have been investigated. Methods: The present study was an experimental study. The liposomal systems were synthesized by the method of thin-film hydration and using Tween-20, cholesterol and soybean phosphatidylcholine. After loading Doxorubicin drug into the Liposomes, physiochemical properties of nano-carriers were determined from the perspective of encapsulation efficiency, drug release profile under healthy and cancerous cells condition, hydrodynamic diameter, zeta potential, morphology and IR spectra. Results: The liposomal system had 132. 9 nm in diameter, the encapsulation 93. 74% and-38. 73± 0. 18mV zeta potential. The maximum release of drug from the nano-carrier under conditions 37° C, pH=7. 4 and 42° C, pH=5. 4 and 37° C, pH=5. 4 after 72 hours was 36. 54% and 74. 18% and 55. 9% respectively. SEM and IR assessments revealed spherical morphology and the absence of chemical interaction between nano-carrier and drug. Conclusion: The result of this research indicates that the liposomal system, having the appropriate physiochemical properties, has not changed the chemical nature of drug and thus can be a suitable and semitargeted carrier for Doxorubicin.

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APA: Copy

Moosavizadeh, Seyed Mohammad, Baghiani, Morteza, Majdizadeh, Mohammad, HAGHIRALSADAT, BIBI FATEMEH, & Moosavi zadeh, Seyed Mohamoud. (2019). Experimental study: experimental evaluation of phospholipid system containing doxorubicin HCL for use in chemotherapy. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(11 ), 945-956. SID. https://sid.ir/paper/36310/en

Vancouver: Copy

Moosavizadeh Seyed Mohammad, Baghiani Morteza, Majdizadeh Mohammad, HAGHIRALSADAT BIBI FATEMEH, Moosavi zadeh Seyed Mohamoud. Experimental study: experimental evaluation of phospholipid system containing doxorubicin HCL for use in chemotherapy. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(11 ):945-956. Available from: https://sid.ir/paper/36310/en

IEEE: Copy

Seyed Mohammad Moosavizadeh, Morteza Baghiani, Mohammad Majdizadeh, BIBI FATEMEH HAGHIRALSADAT, and Seyed Mohamoud Moosavi zadeh, “Experimental study: experimental evaluation of phospholipid system containing doxorubicin HCL for use in chemotherapy,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 11 , pp. 945–956, 2019, [Online]. Available: https://sid.ir/paper/36310/en

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