Effect of crataegus oxyacanta on antioxidant status in isoproterenolinduced myocardial infarction in male adult rats

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Karamibonari Amir Reza

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:26 | Issue:11 Page(s): 966-977

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Title

Effect of crataegus oxyacanta on antioxidant status in isoproterenolinduced myocardial infarction in male adult rats

Author(s)

Karamibonari Amir Reza | Issue Writer Certificate

Keywords

IsoperternolQ1

Myocardial infarctionQ3

CrataegusQ1

RatQ2

Abstract

Introdution: Rataegus/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">CRataegus oxycanta (hawthorn) is used in herbal and homeopathic medicine as a cardiotonic. The present study was done to investigate the effect of the Rataegus/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">CRataegus oxycanta on antioxidant status in induced Myocardial infarction in Rat. Methods: In this experimental study, four groups of wistar Rats (200-220g) each comprising 10 animals, were selected for this study. Group I, Rats served as control. Group II Rats were given Isoperternol (85mg/kg body weight) subcutaneously on 15th and 16th days. Group III Rats were given Rataegus/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">CRataegus oxycanta (100mg/kg/day), orally for 30 days. Group IV Rats were given Rataegus/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">CRataegus oxycanta (100mg/kg/day), orally for 30 days and Isoperternol (85mg/kg body weight, subcutaneously) was given on 15th and 16th days. At the end of the experimental period, the Rats were anaesthetized and blood obtained from the heart then Rats were sacrificed and the hearts were removed for biochemical and histological analysis. The activity of malondialdehyde (MDA), catalase, superoxide dismutase (SOD), glutathione peroxidase (GPX) and total antioxidants was studied. Descriptive one-way analysis of variance (ANOVA) was used in different group. Significance was defined as P ≤ 0. 05. Statistical analysis was performed using SPSS software version 16. Results: Rataegus/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">CRataegus significantly reduced plasma and heart tissue MDA levels (p<0. 05) and significantly increased catalase, SOD, GPX and total antioxidant levels versus the group that received only Isoperternol (p<0. 05 ). Rataegus/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">CRataegus also decreased the Rate of edema, inflammatory cell infiltRation and heart tissue necrosis compared to the group that received only Isoperternol. Conclusion: The study confirms the protective effect of Rataegus/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">CRataegus oxycanta against tissue damage and oxidative stress caused by Isoperternol induced Myocardial infarction.

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APA: Copy

Karamibonari, Amir Reza. (2019). Effect of crataegus oxyacanta on antioxidant status in isoproterenolinduced myocardial infarction in male adult rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(11 ), 966-977. SID. https://sid.ir/paper/36312/en

Vancouver: Copy

Karamibonari Amir Reza. Effect of crataegus oxyacanta on antioxidant status in isoproterenolinduced myocardial infarction in male adult rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(11 ):966-977. Available from: https://sid.ir/paper/36312/en

IEEE: Copy

Amir Reza Karamibonari, “Effect of crataegus oxyacanta on antioxidant status in isoproterenolinduced myocardial infarction in male adult rats,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 11 , pp. 966–977, 2019, [Online]. Available: https://sid.ir/paper/36312/en

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