THE EVALUATION OF THE ENDOMETRIAL THICKNESS OF AMENORRHEA BREAST CANCER PATIENTS TREATED WITH TAMOXIFEN

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YOUSEFI Z.; HOMAYIE F.; RAFEI S.

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Paper Information

Journal: Journal of Arak University Medical Sciences Year:2011 | Volume:14 | Issue:5 (58) Page(s): 101-107

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Title

THE EVALUATION OF THE ENDOMETRIAL THICKNESS OF AMENORRHEA BREAST CANCER PATIENTS TREATED WITH TAMOXIFEN

Author(s)

YOUSEFI Z. | HOMAYIE F. | RAFEI S. | Issue Writer Certificate

Keywords

AMENORRHEAQ2

BREAST CANCERQ2

ENDOMETRIAL CANCERQ2

ENDOMETRIAL BIOPSYQ2

ENDOMETRIAL THICKNESSQ2

TAMOXIFENQ2

Abstract

Background: BREAST CANCER is one of the most common cancers in women worldwide and one of its most desirable treatments is TAMOXIFEN. The reported side effect associated with TAMOXIFEN is ENDOMETRIAL THICKNESS and increased risk of ENDOMETRIAL CANCER. The aim of this study was to assess the influence of TAMOXIFEN on the ENDOMETRIAL THICKNESS in AMENORRHEA BREAST CANCER patients treated with TAMOXIFEN.Materials and Methods: This descriptive-analytic, cross-sectional study was conducted in Radiotherapy Departments of Mashhad University of Medical Sciences over a period of seven years.162 patients treated with TAMOXIFEN whose bleeding cycle had been disrupted were selected and the relationship between TAMOXIFEN usage and ENDOMETRIAL THICKNESS was investigated in them. In addition, the relationship between abnormal vaginal bleeding and the ultra sonographic findings was assessed. Data analysis was done by using t-test and Chi-square test.Results: There was a significant relationship between TAMOXIFEN usage and abnormal ENDOMETRIAL THICKNESS while the greatest relationship was observed in the first year of treatment. The relationship between abnormal vaginal bleeding and abnormal endometrial sonographic findings was significant (P=0.001). The incidence of ENDOMETRIAL CANCER in TAMOXIFEN users was more than general population (0.61% vs.0.1%).Conclusion: Considering the findings of this study, in the presence of abnormal sonographic and clinical observations indicating abnormal vaginal bleeding, pathological evaluation of the ENDOMETRIAL BIOPSY should be carried out for patients who use TAMOXIFEN.

Cites

PREDICTOR FACTORS OF HEALTH LOCUS OF CONTROL FOR BREAST SELF-EXAMINATION BASED ON HEALTH BELIEF MODEL

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APA: Copy

YOUSEFI, Z., HOMAYIE, F., & RAFEI, S.. (2011). THE EVALUATION OF THE ENDOMETRIAL THICKNESS OF AMENORRHEA BREAST CANCER PATIENTS TREATED WITH TAMOXIFEN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), 14(5 (58)), 101-107. SID. https://sid.ir/paper/363406/en

Vancouver: Copy

YOUSEFI Z., HOMAYIE F., RAFEI S.. THE EVALUATION OF THE ENDOMETRIAL THICKNESS OF AMENORRHEA BREAST CANCER PATIENTS TREATED WITH TAMOXIFEN. ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ)[Internet]. 2011;14(5 (58)):101-107. Available from: https://sid.ir/paper/363406/en

IEEE: Copy

Z. YOUSEFI, F. HOMAYIE, and S. RAFEI, “THE EVALUATION OF THE ENDOMETRIAL THICKNESS OF AMENORRHEA BREAST CANCER PATIENTS TREATED WITH TAMOXIFEN,” ARAK MEDICAL UNIVERSITY JOURNAL (AMUJ), vol. 14, no. 5 (58), pp. 101–107, 2011, [Online]. Available: https://sid.ir/paper/363406/en

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