EFFECT OF TRANEXAMIC ACID ON EARLY POSTVITRECTOMY HEMORRHAGE IN DIABETICS

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AHMADIEH H.; RAMEZANI ALI REZA; GHASEMINEZHAD A.KH.; GOLESTAN B.

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Journal: BINA Year:2004 | Volume:9 | Issue:4 (36) Page(s): 357-364

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Information Journal Paper

Title

EFFECT OF TRANEXAMIC ACID ON EARLY POSTVITRECTOMY HEMORRHAGE IN DIABETICS

Author(s)

AHMADIEH H. | RAMEZANI ALI REZA | GHASEMINEZHAD A.KH. | GOLESTAN B. | Issue Writer Certificate

Keywords

TRANEXAMIC ACIDQ3

POSTVITRECTOMY HEMORRHAGEQ3

DIABETICSQ3

Abstract

Purpose: To evaluate the effect of TRANEXAMIC ACID on early POSTVITRECTOMY HEMORRHAGE in diabetic patients.Methods: In a randomized double masked clinical trial, 62 diabetic patients scheduled for vitrectomy were randomly assigned to two groups. The treatment group (32 eyes) received two doses of TRANEXAMIC ACID (10 mg/kg) shortly before and after the operation, intravenously and then orally for 4 days (20 mg/kg/8h). Doses were adjusted according to serum creatinine level. The control group (30 eyes) received no medication. Both media clarity and visual acuity were compared during four weeks of follow up.Results: Four weeks after treatment, visual acuity was low (≤20/1200in) 21.4%, moderate (20/1200 to 20/200) in 14.3%, and good (≥20/200) in 64.3% of the treatment group. Corresponding figures in the control group were 26.1 %, 26.1 %, and 47.8%, respectively. These differences were not statistically significant. The ratio of mild to severe vitreous hemorrhage during the first four days and after four weeks was 79% to 21% and 82% to 18% in the treatment group and 76.7% to 23.3% and 78.3% to 21.7% in the control group respectively, which showed no significant difference. No important side effect of the drug was observed in this study. The only notable finding was a positive correlation between fresh preoperative vitreous hemorrhage and postoperative bleeding.Conclusions: TRANEXAMIC ACID, with the dosage and method of administration in this study, has no effect on reducing early POSTVITRECTOMY HEMORRHAGE in patients with proliferative diabetic retinopathy.

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APA: Copy

AHMADIEH, H., RAMEZANI, ALI REZA, GHASEMINEZHAD, A.KH., & GOLESTAN, B.. (2004). EFFECT OF TRANEXAMIC ACID ON EARLY POSTVITRECTOMY HEMORRHAGE IN DIABETICS. BINA, 9(4 (36)), 357-364. SID. https://sid.ir/paper/363625/en

Vancouver: Copy

AHMADIEH H., RAMEZANI ALI REZA, GHASEMINEZHAD A.KH., GOLESTAN B.. EFFECT OF TRANEXAMIC ACID ON EARLY POSTVITRECTOMY HEMORRHAGE IN DIABETICS. BINA[Internet]. 2004;9(4 (36)):357-364. Available from: https://sid.ir/paper/363625/en

IEEE: Copy

H. AHMADIEH, ALI REZA RAMEZANI, A.KH. GHASEMINEZHAD, and B. GOLESTAN, “EFFECT OF TRANEXAMIC ACID ON EARLY POSTVITRECTOMY HEMORRHAGE IN DIABETICS,” BINA, vol. 9, no. 4 (36), pp. 357–364, 2004, [Online]. Available: https://sid.ir/paper/363625/en

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