Comparing the Effect of Acute and Chronic Cyclophosphamide Administration on Cognitive and Avoidance Memories and Histopathology of the Hippocampus in Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Eskandari Ashraf; KESMATI MAHNAZ; REZAIE ANNAHITA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2019 | Volume:29 | Issue:177 Page(s): 1-12

Download Full-Text

Persian Verion

View:

301

Download:

Cites:

Information Journal Paper

Title

Comparing the Effect of Acute and Chronic Cyclophosphamide Administration on Cognitive and Avoidance Memories and Histopathology of the Hippocampus in Mice

Author(s)

Eskandari Ashraf | KESMATI MAHNAZ | REZAIE ANNAHITA | Issue Writer Certificate

Keywords

cyclophosphamideQ2

passive avoidance memoryQ1

new object recognitionQ1

hippocampusQ2

Abstract

Background and purpose: The quality of life in patients with cancer is affected by cognitive changes after chemotherapy. There are different reports about the effect of cyclophosphamide as a chemotherapy agent on cognitive function. So, the present study aimed to investigate the effects of acute and chronic injections of cyclophosphamide on passive avoidance and novel object recognition memory in an animal model. Materials and methods: In this experimental study, 56 male mice (weighing 30± 5g) were investigated in 8 groups, including a control group (saline) and a group that received cyclophosphamide with acute injection (single dose) and two similar groups with chronic injection (4 injections per week for 4 weeks) for passive avoidance test. In the next four groups the novel object recognition test was performed. cyclophosphamide was injected at 50 mg/kg intraperitoneally and before training. In order to investigate the histopathology of the hippocampal tissue, the brains of the mice were removed after the tests. Data were analyzed applying independent t-test in SPSS. Results: Acute cyclophosphamide administration had no significant effect on the two types of memory, but in chronic injections, it decreased the passive avoidance memory (P<0. 05), while it did not affect cognitive memory. Ischemic changes were observed in neurons CA1 to CA3 (Cornu Ammonis areas) and DG (Dentate Gyrus) hippocampal in chronic cyclophosphamide administration. Conclusion: cyclophosphamide was not found to affect all aspects of memory, and the avoidance memory impairment due to its chronic administration seems to be due to neurological damage to the hippocampus.

Cites

No record.

References

No record.

Cite

APA: Copy

Eskandari, Ashraf, KESMATI, MAHNAZ, & REZAIE, ANNAHITA. (2019). Comparing the Effect of Acute and Chronic Cyclophosphamide Administration on Cognitive and Avoidance Memories and Histopathology of the Hippocampus in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(177 ), 1-12. SID. https://sid.ir/paper/363739/en

Vancouver: Copy

Eskandari Ashraf, KESMATI MAHNAZ, REZAIE ANNAHITA. Comparing the Effect of Acute and Chronic Cyclophosphamide Administration on Cognitive and Avoidance Memories and Histopathology of the Hippocampus in Mice. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;29(177 ):1-12. Available from: https://sid.ir/paper/363739/en

IEEE: Copy

Ashraf Eskandari, MAHNAZ KESMATI, and ANNAHITA REZAIE, “Comparing the Effect of Acute and Chronic Cyclophosphamide Administration on Cognitive and Avoidance Memories and Histopathology of the Hippocampus in Mice,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 177 , pp. 1–12, 2019, [Online]. Available: https://sid.ir/paper/363739/en

Related Journal Papers