Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients with Cardiovascular Diseases

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Amirkhani Fahimeh; Namazi Gholamreza; Hayatmoghadam Bentolhoda; POURFARZAM MORTEZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Isfahan Medical School Year:2019 | Volume:37 | Issue:523 Page(s): 385-391

Download Full-Text

Persian Verion

View:

447

Download:

Cites:

Information Journal Paper

Title

Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients with Cardiovascular Diseases

Author(s)

Amirkhani Fahimeh | Namazi Gholamreza | Hayatmoghadam Bentolhoda | POURFARZAM MORTEZA | Issue Writer Certificate

Keywords

Coronary artery stenosisQ1

CholesterolQ3

Gas chromatography-mass spectrometryQ1

Abstract

Background: Nowadays, coronary artery diseases (CADs) are among the most common diseases in societies. The aim of this study was to study the interplay between Cholesterol absorption and synthesis in two groups of Iranian patients with CAD by measuring the markers of Cholesterol synthesis and absorption pathways in plasma. Methods: The study population included 128 patients undergoing clinically indicated coronary angiography. Patients were divided into two groups after scoring the severity of their coronary stenosis; the S-stenosis group (patients with CAD, n = 75) had a significant stenosis indicated by coronary angiography, and the second group, N-stenosis (n = 55), had no significant coronary stenosis. Fasting plasma samples were used to measure Cholesterol absorption and synthesis markers by Gas chromatography-mass spectrometry (GC-MS). Findings: The level of Cholesterol absorption markers in patients with Coronary artery stenosis was slightly increased compared to patients without Coronary artery stenosis, but this change was statistically significant only for cholestanol (P < 0. 050). In terms of Cholesterol synthesis markers, the results did not show any significant differences between the two groups (P > 0. 050 for all). Conclusion: Study of Cholesterol synthesis and absorption markers has not been reported in Iranian patients before. This article reports the results of such study for the first time. Considering the high prevalence of CADs and the importance of Cholesterol metabolism in pathology of these diseases, the results may be used to understand some underlying mechanisms of development and progression of these diseases, and to manage the patient better.

Cites

No record.

References

No record.

Cite

APA: Copy

Amirkhani, Fahimeh, Namazi, Gholamreza, Hayatmoghadam, Bentolhoda, & POURFARZAM, MORTEZA. (2019). Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients with Cardiovascular Diseases. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 37(523 ), 385-391. SID. https://sid.ir/paper/363807/en

Vancouver: Copy

Amirkhani Fahimeh, Namazi Gholamreza, Hayatmoghadam Bentolhoda, POURFARZAM MORTEZA. Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients with Cardiovascular Diseases. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2019;37(523 ):385-391. Available from: https://sid.ir/paper/363807/en

IEEE: Copy

Fahimeh Amirkhani, Gholamreza Namazi, Bentolhoda Hayatmoghadam, and MORTEZA POURFARZAM, “Evaluation of Cholesterol Synthesis and Absorption Pathways in Patients with Cardiovascular Diseases,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 37, no. 523 , pp. 385–391, 2019, [Online]. Available: https://sid.ir/paper/363807/en

Related Journal Papers