Study of Vitis vinifera L. seed's hydroethanolic extract on blood parameters in male rats induced with cyclophosphamide

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Taherkhani Behnam; MIRAZI NASER

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:7 Page(s): 24-32

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Title

Study of Vitis vinifera L. seed's hydroethanolic extract on blood parameters in male rats induced with cyclophosphamide

Author(s)

Taherkhani Behnam | MIRAZI NASER | Issue Writer Certificate

Keywords

Vitis vinifera seed's extractQ1

CyclophosphamideQ2

Blood parametersQ1

Abstract

Background: Cyclofosfamide has damage effect on bone marrow and changes Blood parameters. The seed of Vitis vinifera L. has anti-oxidants, anti-inflammatory and antibacterial effects. The aim of this study is to investigate the Vitis vinifera' seed extract (VSE) on Blood parameters in male rat treated by cyclofosfamide. Methods and Material: 42 adult male Wistar rats (220± 20 gr) were devided into 6 groups (n=7) randomly. The control group (0. 5 ml normal saline-daily, i. p), witness group (15 mg/kg Cyclophosphamide, i. p), positive control group (200mg/kg VSE, i. p), treated groups1, 2 & 3 (100 mg/kg, 200 mg/kg & 400 mg/kg VSE + 15 mg/kg Cyclophosphamide daily, i. p, for 10 days). At the end of examinations, the animals were anesthetized with ethyl ether and blood samples were collected from heart directly. The Blood parameters such as RBC, WBC, PL, HB and Hct were analysed. Results: The blood cells and platelets were decreased in witness group comparing with control group significantly (p<0. 001). The RBC, WBC, PL and hemoglobin significantly increased in positive control group compare to Cyclophosphamide treated group (p<0. 001). In treated groups with Cyclophosphamide + VSE the blood cells and PL increased significantly compared with witness group (p<0. 01). Conclusion: The use of VSE has protective effects on Blood parameters in rats induced with Cyclophosphamide.

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APA: Copy

Taherkhani, Behnam, & MIRAZI, NASER. (2019). Study of Vitis vinifera L. seed's hydroethanolic extract on blood parameters in male rats induced with cyclophosphamide. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(7 ), 24-32. SID. https://sid.ir/paper/363808/en

Vancouver: Copy

Taherkhani Behnam, MIRAZI NASER. Study of Vitis vinifera L. seed's hydroethanolic extract on blood parameters in male rats induced with cyclophosphamide. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(7 ):24-32. Available from: https://sid.ir/paper/363808/en

IEEE: Copy

Behnam Taherkhani, and NASER MIRAZI, “Study of Vitis vinifera L. seed's hydroethanolic extract on blood parameters in male rats induced with cyclophosphamide,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 7 , pp. 24–32, 2019, [Online]. Available: https://sid.ir/paper/363808/en

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