RELATIONSHIP BETWEEN LEVEL OF T3 AND CARDIOVASCULAR RISK FACTORS IN TEHRAN LIPID AND GLUCOSE STUDY

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HOSSEINI ROUYA; AINY E.; MIRMIRAN PARVIN; HEYDARIAN P.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2005 | Volume:6 | Issue:4 (SN 24) Page(s): 0-0

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Title

RELATIONSHIP BETWEEN LEVEL OF T3 AND CARDIOVASCULAR RISK FACTORS IN TEHRAN LIPID AND GLUCOSE STUDY

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Keywords

CARDIOVASCULAR RISK FACTORSQ4

LEVEL OF T3Q3

MMORTALITYQ4

Abstract

Introduction: Despite recent literature indicating the association between low T3 levels and cardiovascular mortality in cardiac patients, the relationship between levels of T3 and CARDIOVASCULAR RISK FACTORS in normal populations has not yet been investigated. Considering the increased mortality due to coronary artery disease in our country and the necessity to identify new risk factors, this study was performed to determine the relationship between T3 concentration and CARDIOVASCULAR RISK FACTORS, in individuals, aged over 50, selected from among participants of the Tehran Glucose & Lipid Study (TLGS) population. Materials and methods: The first phase of “Tehran Thyroid study” was performed within the framework of the TLGS with the aim of determining the prevalence of thyroid disorders in a subgroup of subjects of the TLGS. The population of the present study consists of subjects, aged over 50, selected from among the participants of the “Tehran Thyroid study”. In 250 adults, aged > 50 yrs, the LEVEL OF T3 was measured and the relationship between CARDIOVASCULAR RISK FACTORS and T3 concentration was investigated. This relationship was also investigated in two subgroups of these subjects, patients with “diabetes mellitus and IGT” & subjects with ECG evidence of myocardial infarction. Since all subjects had normal T3, quartiles for T3 in normal range were calculated; first quartile: T3<132, second quartile: 1323<149, third quartile: 1503<167 and fourth quartile: T3 ≥ 168 ng/dL. Results: Mean age of subjects was 59.3±6.5 years. Of 250 individuals, 55.2% were men and 44.8% women. There was no statistically significant difference or relationship between variables including age, sex, BMI, waist, systolic and diastolic blood pressure, smoking, FBS, BS and status of angina pectoris on the basis of “Rose questionnaire” in T3 quartiles. A weak and positive but statistically significant relationship between T3 and total cholesterol and LDL-C and TG was seen (r= 0.16, P= 0.008 for total cholesterol; r= 0.13, P= 0.03 for LDL-C and r= 0.18, P= 0.003 for TG). The cumulative frequency of CARDIOVASCULAR RISK FACTORS in T3 quartiles showed no statistically significant differences (P= 0.36). In diabetic and IGT subjects (n=96) and also in patients with ECG evidence of MI (n= 27), there was no statistically significant relationship between LEVEL OF T3 and CARDIOVASCULAR RISK FACTORS. Conclusion: This study showed that there was no relationship between LEVEL OF T3 and CARDIOVASCULAR RISK FACTORS in a Tehranian population aged over 50 years.

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APA: Copy

HOSSEINI, ROUYA, AINY, E., MIRMIRAN, PARVIN, HEYDARIAN, P.. (2005). RELATIONSHIP BETWEEN LEVEL OF T3 AND CARDIOVASCULAR RISK FACTORS IN TEHRAN LIPID AND GLUCOSE STUDY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 6(4 (SN 24)), 0-0. SID. https://sid.ir/paper/364346/en

Vancouver: Copy

HOSSEINI ROUYA, AINY E., MIRMIRAN PARVIN, HEYDARIAN P.. RELATIONSHIP BETWEEN LEVEL OF T3 AND CARDIOVASCULAR RISK FACTORS IN TEHRAN LIPID AND GLUCOSE STUDY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2005;6(4 (SN 24)):0-0. Available from: https://sid.ir/paper/364346/en

IEEE: Copy

ROUYA HOSSEINI, E. AINY, PARVIN MIRMIRAN, P. HEYDARIAN, “RELATIONSHIP BETWEEN LEVEL OF T3 AND CARDIOVASCULAR RISK FACTORS IN TEHRAN LIPID AND GLUCOSE STUDY,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 6, no. 4 (SN 24), pp. 0–0, 2005, [Online]. Available: https://sid.ir/paper/364346/en

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