ANTIBACTERIAL EFFECTS OF GOLD NANOPARTICLES ON MULTI-SDRUG RESISTANT KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI AND ITS EFFECT ON THE LIVER OF BALB/C MICE

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RAHIMZADE TORABI L.; DOUDI M.; NOORI A.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2016 | Volume:23 | Issue:10 Page(s): 1001-1017

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Title

ANTIBACTERIAL EFFECTS OF GOLD NANOPARTICLES ON MULTI-SDRUG RESISTANT KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI AND ITS EFFECT ON THE LIVER OF BALB/C MICE

Author(s)

RAHIMZADE TORABI L. | DOUDI M. | NOORI A. | Issue Writer Certificate

Keywords

BALB/C MICEQ1

ESCHERICHIA COLIQ1

GOLD NANOPARTICLESQ1

KLEBSIELLA PNEUMONIAEQ2

LIVERQ2

MULTI DRUG RESISTANT (MDR)Q3

Abstract

Introduction: The GOLD NANOPARTICLES as other nanoparticles have catalytic, magnetic, optical, and biological (antimicrobial) properties. On the other hand, resistance to antibiotics is one of the greatest public health problems posed in the world. Therefore, the present study aimed to investigate the antibacterial effects of GOLD NANOPARTICLES on multi-drug resistant KLEBSIELLA PNEUMONIAE as well as ESCHERICHIA COLI and its effect on the LIVER of BALB/C MICE.Methods: In this study, multi-drug resistant KLEBSIELLA PNEUMONIAE and ESCHERICHIA COLI bacteria clinical samples were utilized that were isolated from several hospitals in Isfahan and then the toxic effects of nanoparticles were investigated on the Balb / C mice. Colloidal GOLD NANOPARTICLES were also applied with spherical shape and a concentration of 200 ppm in size of 10 nm, using two wells and disk agar diffusion method. Antibacterial properties of the nanoparticles were evaluated within 1-3 days with 37oc temperature, and diameter of inhibitory zone of growth was measured every day. Tissue and LIVER enzymes of the mice were examined, as well.Results: The greatest diameter of inhibitory zone was detected in multi drug resistant E. coli. Most of the MIC and MBC were found in multi-drug resistant KLEBSIELLA PNEUMONIAE bacteria. GOLD NANOPARTICLES did not reveal any significant changes on the weight, LIVER enzymes and LIVER tissue of Balb / C mice after one month.Conclusion: As the findings of the current study revealed, inhibitory effect of GOLD NANOPARTICLES was observed on the axamined microorganism. Although the laboratories findings are promising, more studies should be conducted in regard with therapeutic standardization.

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APA: Copy

RAHIMZADE TORABI, L., DOUDI, M., & NOORI, A.. (2016). ANTIBACTERIAL EFFECTS OF GOLD NANOPARTICLES ON MULTI-SDRUG RESISTANT KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI AND ITS EFFECT ON THE LIVER OF BALB/C MICE. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 23(10), 1001-1017. SID. https://sid.ir/paper/36476/en

Vancouver: Copy

RAHIMZADE TORABI L., DOUDI M., NOORI A.. ANTIBACTERIAL EFFECTS OF GOLD NANOPARTICLES ON MULTI-SDRUG RESISTANT KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI AND ITS EFFECT ON THE LIVER OF BALB/C MICE. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;23(10):1001-1017. Available from: https://sid.ir/paper/36476/en

IEEE: Copy

L. RAHIMZADE TORABI, M. DOUDI, and A. NOORI, “ANTIBACTERIAL EFFECTS OF GOLD NANOPARTICLES ON MULTI-SDRUG RESISTANT KLEBSIELLA PNEUMONIAE AND ESCHERICHIA COLI AND ITS EFFECT ON THE LIVER OF BALB/C MICE,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 10, pp. 1001–1017, 2016, [Online]. Available: https://sid.ir/paper/36476/en

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