Effect of endurance training on protein expression of CGI-58, ATGL and serum levels of insulin and glucose in streptozotocin-induced diabetic rats

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Dashti khavidaki Mohammad Hassan; FARAMARZI MOHAMMAD; AZAMIAN JAZI AKBAR; BANITALEBI EBRAHIM

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2018 | Volume:26 | Issue:1 Page(s): 85-96

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Title

Effect of endurance training on protein expression of CGI-58, ATGL and serum levels of insulin and glucose in streptozotocin-induced diabetic rats

Author(s)

Dashti khavidaki Mohammad Hassan | FARAMARZI MOHAMMAD | AZAMIAN JAZI AKBAR | BANITALEBI EBRAHIM | Issue Writer Certificate

Keywords

CGI-58Q1

ATGLQ1

endurance exerciseQ1

insulinQ2

glucoseQ2

Abstract

IntrodutionThe purpose of this study was investigating the effect of endurance training on protein expression of CGI-58, ATGL and serum levels of insulin and glucose in streptozotocin-induced diabetic rats. Methods: 42 male Wistar rats were randomly assigned to three groups of eight, including diabetic group with endurance exercise (D-E), diabetic (D) and healthy control groups (Con). After induction of diabetic rats by injection streptozotocin was administered intraperitoneal, endurance exercise was applied for eight weeks, three sessions pre week in diabetic rats. Exercise intensity was equal to a speed of 42-42 m / min. The relative expression of CGI-58 and ATGL protein was measured with western blot technique and serum insulin and glucose levels were measured with a specialized kit. One-way ANOVA test was performed using SPSS-42 software and at a significance level less than %2. Results: Results showed that ATGL and CGI-58 values were significantly different between the three groups (p <2. 222). ATGL difference between the groups of diabetic group with endurance exercise with control (p = 2. 222) and diabetic (p = 2. 222)was significant. CGI-58 difference between the groups of diabetic group with endurance exercise with control (p = 2. 222) and diabetic (p = 2. 224) was significant. In addition, serum glucose and insulin levels decreased significantly after eight weeks of training (p <2. 22). Conclusion: It seems that CGI-58 play a vital role in activating lipolysis by ATGL and increasing in CGI-58 leads to an increase in ATGL and ultimately leads to increased levels of intramuscular triglyceride oxidation and improved insulin resistance.

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APA: Copy

Dashti khavidaki, Mohammad Hassan, FARAMARZI, MOHAMMAD, AZAMIAN JAZI, AKBAR, & BANITALEBI, EBRAHIM. (2018). Effect of endurance training on protein expression of CGI-58, ATGL and serum levels of insulin and glucose in streptozotocin-induced diabetic rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 26(1 ), 85-96. SID. https://sid.ir/paper/36506/en

Vancouver: Copy

Dashti khavidaki Mohammad Hassan, FARAMARZI MOHAMMAD, AZAMIAN JAZI AKBAR, BANITALEBI EBRAHIM. Effect of endurance training on protein expression of CGI-58, ATGL and serum levels of insulin and glucose in streptozotocin-induced diabetic rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(1 ):85-96. Available from: https://sid.ir/paper/36506/en

IEEE: Copy

Mohammad Hassan Dashti khavidaki, MOHAMMAD FARAMARZI, AKBAR AZAMIAN JAZI, and EBRAHIM BANITALEBI, “Effect of endurance training on protein expression of CGI-58, ATGL and serum levels of insulin and glucose in streptozotocin-induced diabetic rats,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 1 , pp. 85–96, 2018, [Online]. Available: https://sid.ir/paper/36506/en

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