The Effect of Pomegranate and Its Compounds on Breast Cancer: Review Article

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Esmaeilinezhad Zahra; Barati Boldaji Reza

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Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:27 | Issue:8 Page(s): 1814-1825

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Information Journal Paper

Title

The Effect of Pomegranate and Its Compounds on Breast Cancer: Review Article

Author(s)

Esmaeilinezhad Zahra | Barati Boldaji Reza | Issue Writer Certificate

Keywords

CancerQ3

PunicaceaeQ1

MetastasisQ2

ApoptosisQ1

Abstract

Introduction: Pomegranate is a rich source of phytochemicals with high antioxidant effects, which has therapeutic effects in traditional and modern medicine. Pomegranate is effective in the prevention and treatment of cardiovascular diseases, diabetes, obesity, inflammatory diseases, infectious and microbial diseases, neurological disorders and immunity. Today the role of pomegranate in various stages of Cancer has also been proven. Since breast Cancer is one of the most common Cancers among women, this study examined the effect of pomegranate in breast Cancer. The articles used from the PubMed database were selected selectively using the words "pomegranate" or "Punica grantum" and "breast Cancer". The results of studies have shown that pomegranate compounds can affect different stages of Cancer in different ways, including: inhibiting aromatases, inhibiting cyclooxygenase enzymeseffects on heat shock proteins, transcriptional leukocyte zipper transcription factor, transcription factors of specific proteins, cell cycle. Also, it has been shown in some studies that pomegranate compounds canaffect different stages of Cancerthroughanti-estrogenic activity, effect on 27-hydroxycholic cholesterol, changes in α and β estrogen receptors, Wnt / β-catenin signaling pathway, Cancer cell adhesion and migration, effects on cytochrome p450, Caspase cascade, Apoptosis and other pathways.

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APA: Copy

Esmaeilinezhad, Zahra, & Barati Boldaji, Reza. (2019). The Effect of Pomegranate and Its Compounds on Breast Cancer: Review Article. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 27(8 ), 1814-1825. SID. https://sid.ir/paper/36532/en

Vancouver: Copy

Esmaeilinezhad Zahra, Barati Boldaji Reza. The Effect of Pomegranate and Its Compounds on Breast Cancer: Review Article. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(8 ):1814-1825. Available from: https://sid.ir/paper/36532/en

IEEE: Copy

Zahra Esmaeilinezhad, and Reza Barati Boldaji, “The Effect of Pomegranate and Its Compounds on Breast Cancer: Review Article,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 8 , pp. 1814–1825, 2019, [Online]. Available: https://sid.ir/paper/36532/en

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