Association of Metformin Pharmacogenetic with a Single Amino Acid Alteration in Peroxisome Proliferator-Activated Receptor Gamma (PPARγ ) Genein Patients with Polycystic Ovary Syndrome

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JAFARI FATEMEH; MIRESMAEILI SEYED MOHSEN; KALANTAR SEYED MEHDI

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Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:27 | Issue:8 Page(s): 1795-1803

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Information Journal Paper

Title

Association of Metformin Pharmacogenetic with a Single Amino Acid Alteration in Peroxisome Proliferator-Activated Receptor Gamma (PPARγ ) Genein Patients with Polycystic Ovary Syndrome

Author(s)

JAFARI FATEMEH | MIRESMAEILI SEYED MOHSEN | KALANTAR SEYED MEHDI | Issue Writer Certificate

Keywords

Pharmacogenetic analysisQ1

Polycystic ovary syndromeQ2

PPAR gammaQ1

MetforminQ2

Abstract

Introduction: Polycystic ovarian syndrome (PCOS) is known as a metabolic, reproductive and ovarian degeneration disorder. Pro12Ala mutation in peroxisome proliferator-activated receptor gamma (PPARγ ) gene as a transcription factor is linked to disorder of glucose and infertility. In the patients with type 2 diabetes and Polycystic ovary syndrome, Metforminis the recommended first-line treatment. The aim of this study was evaluation of pharmacokinetics of Metformin and the patients genotype for Pro12Ala polymorphism. Methods: In this study, 100 women with PCOS and 100 healthy women were evaluated. Plasma levels of the FSH and LH were evaluated before and after Metformin consumption in the patients. The Pro12Ala polymorphism was detected by PCR-RFLP analysis. Results: Two patients carried GG homozygousrecessive. There was no significant difference in genotypes between the healthy and patient women. There was a significant difference in plasma levels of LH, FSH and testosterone before and after treatment with Metformin but there was no relationship between genotype and response to Metformin (p-value = 0. 59). Conclusion: Considering to this research, there is no relationship between Pro12Ala polymorphism and Metformin response in the patients, but the response to Metformin for the regulation and improvement ovulation hormones in many patients is satisfactory.

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References

Polycystic Ovary Syndrome is a Risk Factor for Diabetes and Prediabetes in Middle-Aged But Not Elderly Women: A Long-Term Population-Based Follow-Up Study

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APA: Copy

JAFARI, FATEMEH, MIRESMAEILI, SEYED MOHSEN, & KALANTAR, SEYED MEHDI. (2019). Association of Metformin Pharmacogenetic with a Single Amino Acid Alteration in Peroxisome Proliferator-Activated Receptor Gamma (PPARγ ) Genein Patients with Polycystic Ovary Syndrome. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 27(8 ), 1795-1803. SID. https://sid.ir/paper/36535/en

Vancouver: Copy

JAFARI FATEMEH, MIRESMAEILI SEYED MOHSEN, KALANTAR SEYED MEHDI. Association of Metformin Pharmacogenetic with a Single Amino Acid Alteration in Peroxisome Proliferator-Activated Receptor Gamma (PPARγ ) Genein Patients with Polycystic Ovary Syndrome. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(8 ):1795-1803. Available from: https://sid.ir/paper/36535/en

IEEE: Copy

FATEMEH JAFARI, SEYED MOHSEN MIRESMAEILI, and SEYED MEHDI KALANTAR, “Association of Metformin Pharmacogenetic with a Single Amino Acid Alteration in Peroxisome Proliferator-Activated Receptor Gamma (PPARγ ) Genein Patients with Polycystic Ovary Syndrome,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 8 , pp. 1795–1803, 2019, [Online]. Available: https://sid.ir/paper/36535/en

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