Comparison of the apoptotic effects of TPSF small molecule and hydroalcoholic extract of Ziziphus spina-christi on cervical cancer cells

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hushmandi Kiavash; HOVEIZI ELHAM; Gooraninejad Saad; TABANDEH MOHAMMAD REZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Feyz Medical Sciences Journal Year:2020 | Volume:24 | Issue:1 Page(s): 21-30

Download Full-Text

Persian Verion

View:

297

Download:

Cites:

Information Journal Paper

Title

Comparison of the apoptotic effects of TPSF small molecule and hydroalcoholic extract of Ziziphus spina-christi on cervical cancer cells

Author(s)

Hushmandi Kiavash | HOVEIZI ELHAM | Gooraninejad Saad | TABANDEH MOHAMMAD REZA | Issue Writer Certificate

Keywords

Cervical cancerQ2

Ziziphus Spina-christi leaveQ1

TPSFQ1

Small moleculeQ1

Abstract

Background: Cervical cancer is the third most common cancer in the world. Considering the prevalence of Cervical cancer in Iran and unsuccessful treatments, the apoptotic effects of TPSF Small molecule investigated in comparison with the hydroelectric extract of Ziziphus Spina-christi leaves on the Cervical cancer cell line (HeLa). Materials and Methods: HeLa cells were cultured in a DMEM medium containing 10% FBS, and treated with different concentrations of TPSF and extract on days 1, 3 and 5. Apoptotic effects were investigated using MTT method, and the morphology of cells was studied by Giemsa staining using invert microscope. Results: 2 μ m concentration of TPSF was determined in 24 hours as IC50 for HeLa cells. The percentage of viability in cells treated with 0. 5, 1, 2, 5, and 10 μ M TPSF was 78, 63, 50, 42 and 37%. The concentration of 4 mM hydroalcoholic extract was determined as IC50 of HeLa cells in 24 hours. The percentage of viability in treated cells with 1, 2, 4, 6 and 8 mM from the extract of was 73, 61, 50, 41, and 37. The results showed a significant (P≤ 0. 05) decrease compared with the control samples. Also, morphological results showed that the treated cells indicated notable changes such as the shrunk nucleus, damaged membrane, and wrinkled cytoplasm compared with the control sample. Conclusion: The TPSF is significantly better than the extract of Ziziphus Spina-christi, it can be concluded that Small molecules have the smallest amount of cytotoxic effect on HeLa cells and have a greater apoptotic effect.

Cites

No record.

References

Cite

APA: Copy

Hushmandi, Kiavash, HOVEIZI, ELHAM, Gooraninejad, Saad, & TABANDEH, MOHAMMAD REZA. (2020). Comparison of the apoptotic effects of TPSF small molecule and hydroalcoholic extract of Ziziphus spina-christi on cervical cancer cells. FEYZ, 24(1 ), 21-30. SID. https://sid.ir/paper/365708/en

Vancouver: Copy

Hushmandi Kiavash, HOVEIZI ELHAM, Gooraninejad Saad, TABANDEH MOHAMMAD REZA. Comparison of the apoptotic effects of TPSF small molecule and hydroalcoholic extract of Ziziphus spina-christi on cervical cancer cells. FEYZ[Internet]. 2020;24(1 ):21-30. Available from: https://sid.ir/paper/365708/en

IEEE: Copy

Kiavash Hushmandi, ELHAM HOVEIZI, Saad Gooraninejad, and MOHAMMAD REZA TABANDEH, “Comparison of the apoptotic effects of TPSF small molecule and hydroalcoholic extract of Ziziphus spina-christi on cervical cancer cells,” FEYZ, vol. 24, no. 1 , pp. 21–30, 2020, [Online]. Available: https://sid.ir/paper/365708/en

Related Journal Papers