ANALGESIC EFFECT OF ALCOHOLIC DATURA STRAMONIUM L. SEED EXTRACT ON STEREPTOZOTOCINE-INDUCED DIABETIC MALE RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

KHALILI NAJAFABADI M.; RAHMATI B.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Medicinal Plants Year:2005 | Volume:4 | Issue:14 Page(s): 0-0

Download Full-Text

Persian Verion

View:

1,152

Download:

Cites:

Information Journal Paper

Title

ANALGESIC EFFECT OF ALCOHOLIC DATURA STRAMONIUM L. SEED EXTRACT ON STEREPTOZOTOCINE-INDUCED DIABETIC MALE RATS

Author(s)

KHALILI NAJAFABADI M. | RAHMATI B. | Issue Writer Certificate

Keywords

DIABETESQ3

PAINQ3

DATURA STRAMONIUMQ2

STREPTOZOTOCINQ2

RATQ3

Abstract

Background: Hyperalgesia and allodynia are two of the most critcal debilitating symptoms in patients with DIABETES mellitus. In this study, the threshold of the acute and chronic PAIN was measured using formalin and hot plate tests in male RATs. In another experiments, we studied the anti-hyperalgesic effect of alcoholic Datura seed extract in diabetic RATs. Objective: The aim of this study was to investigate the effect of alcoholic DATURA STRAMONIUM seed extract on hyperalgesia induced by diabetic mellitus. Method: Experimental animals were made diabetic (n=12-15) using a single dose of STREPTOZOTOCIN (STZ, 60 mg/kg, i.p). After 30 days their PAIN threshold in each test group was compared with control group (n=12-15). Results: Our statistical data analysis showed that the acute and chronic PAINs arising from formalin and hot plate tests were markedly augmented due to diabeties mellitus. In additional experiments we assessed the acute and chronic PAIN in groups 1-control+extract (n=12-15) and 2-diabetic+extract (n=12-15). The extract was administered for 30 days every other day. The results showed that the extract (over than 50 mg/kg/BW) could significantly diminish the augmented acute PAIN in hot plate and formalin tests. In contrast, chronic formalin PAIN did not change by the extract in dosage of 50 mg/kg/BW and over. Conclusion: The acute PAIN in hot plate and first phase of formalin tests were significantly augmented due to DIABETES mellitus. Also, it was shown that the Datura seed extract could have diminished the augmented acute PAIN in both tests, but chronic formalin PAIN could not be influenced by doses of the extract higher than 50 mg/kg/BW.

Cites

EVALUATION OF THE EFFECT OF HYDRO-ALCOHOLIC EXTRACT OF HENBANE SEED ON ACUTE AND CHRONIC PAIN IN MALE RATS

References

Cite

APA: Copy

KHALILI NAJAFABADI, M., & RAHMATI, B.. (2005). ANALGESIC EFFECT OF ALCOHOLIC DATURA STRAMONIUM L. SEED EXTRACT ON STEREPTOZOTOCINE-INDUCED DIABETIC MALE RATS. JOURNAL OF MEDICINAL PLANTS, 4(14), 0-0. SID. https://sid.ir/paper/365778/en

Vancouver: Copy

KHALILI NAJAFABADI M., RAHMATI B.. ANALGESIC EFFECT OF ALCOHOLIC DATURA STRAMONIUM L. SEED EXTRACT ON STEREPTOZOTOCINE-INDUCED DIABETIC MALE RATS. JOURNAL OF MEDICINAL PLANTS[Internet]. 2005;4(14):0-0. Available from: https://sid.ir/paper/365778/en

IEEE: Copy

M. KHALILI NAJAFABADI, and B. RAHMATI, “ANALGESIC EFFECT OF ALCOHOLIC DATURA STRAMONIUM L. SEED EXTRACT ON STEREPTOZOTOCINE-INDUCED DIABETIC MALE RATS,” JOURNAL OF MEDICINAL PLANTS, vol. 4, no. 14, pp. 0–0, 2005, [Online]. Available: https://sid.ir/paper/365778/en

Related Journal Papers