Inhibitory effects of Nigella sativa nano-capsule on the expression of cyclin D1 in the lungs of wistar rats exposed to nicotine-derived nitrosamine ketone

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NIKZAD MOHAMMADBAGHER; MIRDAR SHADMEHR

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Journal: Journal of Medicinal Plants Year:2020 | Volume:19 | Issue:74 Page(s): 118-128

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Title

Inhibitory effects of Nigella sativa nano-capsule on the expression of cyclin D1 in the lungs of wistar rats exposed to nicotine-derived nitrosamine ketone

Author(s)

NIKZAD MOHAMMADBAGHER | MIRDAR SHADMEHR | Issue Writer Certificate

Keywords

Cell cycleQ1

Cyclin D1 geneQ1

Lung cancerQ1

NicotineQ1

Nitrosamine KetoneQ1

Nigella sativa nano-capsuleQ1

Abstract

Background: Researchers argue that supplements are somewhat capable of influencing the lung tissue exposed to smoking carcinogens through Cell cycle. Cyclin D1 is a gene involved in Cell cycle. Objective: This study aimed to investigate the effects of 12-week injection of Nigella sativa nano-capsule on the expression of Cyclin D1 of the lung tissue of the rats receiving exposure to Nicotine-Derived Nitrosamine Ketone. Methods: 46 Wistar rats were assigned into five groups: NNK, Supplement, and Supplement, + NNK, Control and Vehicle group. 125 μ g/kg body weight of Nigella sativa nano-capsule supplement was injected subcutaneously into the Supplement and Supplement NNK groups once a week. NKK and Vehicle groups received a weekly dose of 12. 5 mg/kg NNK and distilled water for 12 weeks through subcutaneous injection. After isolating the lung tissue, the expression of the Cyclin D1 gene was measured using Real Time PCR-ABI. One-way ANOVA parametric analysis and Tukey post hoc test were used to analyze the data at the significant level of P ≤ 0. 05. Results: According to the results, the expression of Cyclin 1 gene was relatively reduced in Supplement NNK (P = 0. 003) and Vehicle (P = 0. 001) groups in comparison to the NNK group. Nevertheless, no significant difference was observed among the Supplement, Vehicle, and Control groups. We believe that Nigella sativa nanocapsule supplement reduced the relative changes of Cyclin 1 in the lung tissues exposed to carcinogen NNK. Conclusion: Apparently, this supplement is capable of reducing Cyclin 1 level in Cell cycle; hence, it can reduce the carcinogenic effects of NNK and the negative effects of smoking among other therapeutic methods.

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APA: Copy

NIKZAD, MOHAMMADBAGHER, & MIRDAR, SHADMEHR. (2020). Inhibitory effects of Nigella sativa nano-capsule on the expression of cyclin D1 in the lungs of wistar rats exposed to nicotine-derived nitrosamine ketone. JOURNAL OF MEDICINAL PLANTS, 19(74 ), 118-128. SID. https://sid.ir/paper/365919/en

Vancouver: Copy

NIKZAD MOHAMMADBAGHER, MIRDAR SHADMEHR. Inhibitory effects of Nigella sativa nano-capsule on the expression of cyclin D1 in the lungs of wistar rats exposed to nicotine-derived nitrosamine ketone. JOURNAL OF MEDICINAL PLANTS[Internet]. 2020;19(74 ):118-128. Available from: https://sid.ir/paper/365919/en

IEEE: Copy

MOHAMMADBAGHER NIKZAD, and SHADMEHR MIRDAR, “Inhibitory effects of Nigella sativa nano-capsule on the expression of cyclin D1 in the lungs of wistar rats exposed to nicotine-derived nitrosamine ketone,” JOURNAL OF MEDICINAL PLANTS, vol. 19, no. 74 , pp. 118–128, 2020, [Online]. Available: https://sid.ir/paper/365919/en

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