Diagnostic Value of Serum Levels of Vascular Endothelial Growth Factor as a Marker of Tubal Pregnancy

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Saghafi Flora; Gelini Moghadam Tahereh; MORADI SIAVASH

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Journal: JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:29 | Issue:182 Page(s): 21-30

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Title

Diagnostic Value of Serum Levels of Vascular Endothelial Growth Factor as a Marker of Tubal Pregnancy

Author(s)

Saghafi Flora | Gelini Moghadam Tahereh | MORADI SIAVASH | Issue Writer Certificate

Keywords

tubal pregnancyQ1

VEGFQ1

sensitivityQ3

specificitQ3

Abstract

Background and purpose: tubal pregnancy is a life threatening condition that not only causes mortality but also reduces fertility by less than 50%. In many patients, the level of β hCG does not reach detection threshold, and for definite diagnosis, long-term follow-up considering β hCG titration and transvaginal ultrasonography are needed which could lead to delay in diagnosis and treatment. The aim of this study was to determine the vascular endothelial growth factor (VEGF) levels as a serum biomarker in the diagnosis of tubal pregnancy. Materials and methods: This descriptive study was performed in 103 pregnant women attending Sari Imam Khomeini Hospital, 2018, of whom tubal pregnancy was diagnosed in 50 at 5 to 7. 5 weeks of gestational age and the rest (n=53) had normal intrauterine pregnancy with the same gestational age. An ELISA kit (Bioassay Laboratory-China) was used to measure the levels of serum VEGF. Results: The patients aged 21 to 47 years old (mean age: 31. 2 ± 6. 1 years). The median serum levels of VEGF in the tubal pregnancy group and individuals with normal intrauterine pregnancy were 233. 5 and 157. 9, respectively, indicating significant differences between the two groups (P<0. 0001). When threshold concentrations of a serum VEGF level > 280 pg/ml were used, tubal pregnancy could be distinguished from normal pregnancy with a sensitivity of 86%, specificity of 67. 9%, positive predictive value of 99. 6%, and positive and negative likelihood ratio of 2. 68 and 0. 21, respectively. Conclusion: According to current findings, serum VEGF levels could be of great help in differentiating tubal pregnancy from normal pregnancy with appropriate sensitivity and specificity.

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APA: Copy

Saghafi, Flora, Gelini Moghadam, Tahereh, & MORADI, SIAVASH. (2020). Diagnostic Value of Serum Levels of Vascular Endothelial Growth Factor as a Marker of Tubal Pregnancy. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(182 ), 21-30. SID. https://sid.ir/paper/365951/en

Vancouver: Copy

Saghafi Flora, Gelini Moghadam Tahereh, MORADI SIAVASH. Diagnostic Value of Serum Levels of Vascular Endothelial Growth Factor as a Marker of Tubal Pregnancy. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;29(182 ):21-30. Available from: https://sid.ir/paper/365951/en

IEEE: Copy

Flora Saghafi, Tahereh Gelini Moghadam, and SIAVASH MORADI, “Diagnostic Value of Serum Levels of Vascular Endothelial Growth Factor as a Marker of Tubal Pregnancy,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 182 , pp. 21–30, 2020, [Online]. Available: https://sid.ir/paper/365951/en

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