DETERMINING FACTORS IN CHOOSING DOSE OF DIGOXIN

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MODARES MOSADEGH M.; SADR BAFGHI S.M.H.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2002 | Volume:1 | Issue:2 Page(s): 22-28

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Title

DETERMINING FACTORS IN CHOOSING DOSE OF DIGOXIN

Author(s)

MODARES MOSADEGH M. | SADR BAFGHI S.M.H. | Issue Writer Certificate

Keywords

DIGOXINQ3

DOSEQ3

STEADY STATE CONCENTRATIONQ4

DRUG INTERACTIONQ4

TOXICITYQ2

Abstract

DIGOXIN is one of the main stay of treatment in congestive heart failure and supraventricular arrhythmia that has a narrow therapeutic window. This study was conducted to find whether factors like renal function, creatinine clearance, age, and DRUG INTERACTIONs are considered during the prescription of DIGOXIN. This prospective study was conducted in 1379 in Yazd. Demographic characteristics, disease(s), blood pressure, clinical and para-clinical signs and symptoms, arrhythmias, EKG results, DOSE and duration of DIGOXIN use, and concurrent medications of 152 patients were recorded in the questionnaires. Patients were divided into five groups based on their DIGOXIN DOSE: one tablet/day (A), half a tablet/day (B), one tablet, six days per week (C), one tablet five days per week (D), and half a tablet five days per week (E). Besides, serum DIGOXIN concentrations (SDC), electrolyte, urea and creatinine levels were measured. Then DIGOXIN DOSE was then evaluated based on the aforementioned factors. The average DIGOXIN DOSE was 202.56±62.36 mcg/day and SDC was 0.95± 0.47 ng/ml. Creatinine clearance was on average 55.35± 23.17ml/min/1.73 m2. Mean SDC for groups A, B, C, D, and E were 1.05±0.40, 0.87±0.41, 0.95±0.37, 0.91±0.51, and 0.94±0.16, respectively. There was no significant difference in the creatinine clearance of these five groups. Even though DIGOXIN interactions with quinidine and amiodarone were taken into account, its interactions with triamteren, spironolactone, and verapamil were not. Age and electrolyte disturbances were considered for determining DIGOXIN DOSE. Overall, 26.32% of patient's had SDC's below 0.5 mg/ml, where as 14.47% had concentrations above 1.5 mg/ml. Hospitalization due to DIGOXIN TOXICITY was 1.97%. DIGOXIN dosing was usually based on clinical evaluation and age of the patient without considering renal function and DRUG INTERACTIONs. This led to over or under therapeutic levels in some patients.

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APA: Copy

MODARES MOSADEGH, M., & SADR BAFGHI, S.M.H.. (2002). DETERMINING FACTORS IN CHOOSING DOSE OF DIGOXIN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 1(2), 22-28. SID. https://sid.ir/paper/36612/en

Vancouver: Copy

MODARES MOSADEGH M., SADR BAFGHI S.M.H.. DETERMINING FACTORS IN CHOOSING DOSE OF DIGOXIN. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2002;1(2):22-28. Available from: https://sid.ir/paper/36612/en

IEEE: Copy

M. MODARES MOSADEGH, and S.M.H. SADR BAFGHI, “DETERMINING FACTORS IN CHOOSING DOSE OF DIGOXIN,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 1, no. 2, pp. 22–28, 2002, [Online]. Available: https://sid.ir/paper/36612/en

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