Evaluation the expression of miR-182-3p in blood circulation of patients with breast cancer

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Ghorbanifar Shima; PORNOUR MAJID; Sohrabi Mojtaba

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Journal: Razi Journal of Medical Sciences Year:2020 | Volume:26 | Issue:11 Page(s): 124-133

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Title

Evaluation the expression of miR-182-3p in blood circulation of patients with breast cancer

Author(s)

Ghorbanifar Shima | PORNOUR MAJID | Sohrabi Mojtaba | Issue Writer Certificate

Keywords

miR-182-3pQ2

Breast cancerQ1

miRNAQ1

Abstract

Background: Breast cancer is the most common cancer among women, especially in Asian women. miRNAs are a class of non-coding RNAs that play an important role in controlling gene expression at the post-transcriptional level. miR-182 is a tumor inducer in Breast cancer and its expression in cancer tissue is increased. This study was performed to investigate the changes in miR-182-3p expression in blood plasma of Breast cancer patients and its association with clinical features and its diagnostic value as a biomarker in Breast cancer. Methods: This study is a case-control study. Blood samples were collected from the 30 Patient with Breast cancer and the 30 healthy persons (25 to 65 years) as controls. After plasma isolation, RNA was extracted and cDNA was synthesized. Blood plasma samples of the healthy individuals and the patients with Breast cancer were measured by the Real Time PCR technique. The expression changes of miR-182-3p between plasma samples and its association with stage 1 and stage 2 tumors and clinical characteristics were and analyzed with t-test and one-way ANOVA, respectively. Results: The expression level of miR-182-3p in the blood plasma of patients with Breast cancer was significantly higher than that of healthy individuals (fold change= 606/8, p<0. 001). Also, there was a significant relationship between miR-182-3p expression and early stage disease and stage I, II (p<0. 05). Conclusion: The results of this study showed that miR-182-3p has a significant increase in the blood plasma of people with Breast cancer like cancer tissue. Therefore, it is likely to be used as a biomarker and with more studies and more examples. It can be used as a diagnostic marker in the early and safe diagnosis of Breast cancer in the future.

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APA: Copy

Ghorbanifar, Shima, PORNOUR, MAJID, & Sohrabi, Mojtaba. (2020). Evaluation the expression of miR-182-3p in blood circulation of patients with breast cancer. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(11 ), 124-133. SID. https://sid.ir/paper/366122/en

Vancouver: Copy

Ghorbanifar Shima, PORNOUR MAJID, Sohrabi Mojtaba. Evaluation the expression of miR-182-3p in blood circulation of patients with breast cancer. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2020;26(11 ):124-133. Available from: https://sid.ir/paper/366122/en

IEEE: Copy

Shima Ghorbanifar, MAJID PORNOUR, and Mojtaba Sohrabi, “Evaluation the expression of miR-182-3p in blood circulation of patients with breast cancer,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 11 , pp. 124–133, 2020, [Online]. Available: https://sid.ir/paper/366122/en

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