Preparation, characterization and evaluation the effects of microemulsion containing sesame oil on fibrinogen and factor VII level in animal model

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EBRAHIMI MAHMOUD; KARIMI MOHAMMAD; DEHGHANI FARANAK; Farhadian Nafiseh; GOLMOHAMMADZADEH SHIVA

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Journal: Tehran University Medical Journal Year:2019 | Volume:77 | Issue:3 Page(s): 199-206

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Title

Preparation, characterization and evaluation the effects of microemulsion containing sesame oil on fibrinogen and factor VII level in animal model

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Keywords

animal modelsQ2

atherosclerosisQ3

cardiovascular diseasesQ2

experimental studiesQ1

factor VIIQ1

fibrinogenQ2

sesame oilQ2

surface-active agentsQ1

Abstract

Background: sesame oil can be used to treat cardiovascular diseases, such as atherosclerosis, by reducing the levels of fibrinogen and factor VII. The aim of this study is to prepare a microemulsion containing sesame oil as a drug nanocarrier for improving the aqueous solubility and therapeutic effects of this vegetable oil on the reduction of the fibrinogen and factor VII levels in animal model. Methods: This experimental study was performed for microemulsion preparation and animal test at Ferdowsi University of Mashhad and Cardiovascular Research Center of Mashhad University of Medical Sciences, Mashhad, Iran, respectively, from April 2015 to January 2017. To prepare the microemulsion samples, Tween 80 and span 80 were selected as surfactant couple and surfactant ratios of 8: 1, 9: 1 and 10: 1 were determined for construction of pseudo-ternary phase diagrams. The Zealand white rabbits were categorized in three groups: receiver of base diet group, high cholesterol diet and high cholesterol diet plus microemulsion. Results: The average particle size of the samples was in the range of 16. 64± 0. 1 to 21. 16± 0. 2 nm with a uniform particle size distribution. Zeta potential was in the range of-10. 7 to 18. 4 mV, refraction index was approximately 1. 39. Electrical conductivity coefficient was in the range of 297 to 311 μ z and pH of all the samples were approximately 6. 42 for all samples. All of the microemulsion samples were physically stable and the prepared sample with 9: 1 surfactant ratio was selected to investigate the animal test due to the higher oil percentage in comparison with the other samples that be stable over 6 months. Significant decrease in the levels of fibrinogen and factor VII in the third group of rabbits was observed compared to the other groups. Conclusion: The results of this study showed the effective performance of nanostructured drug delivery systems in the form of microemulsion to improve the aqueous solubility and therapeutic effects of hydrophobic compounds such as vegetable oils.

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APA: Copy

EBRAHIMI, MAHMOUD, KARIMI, MOHAMMAD, DEHGHANI, FARANAK, Farhadian, Nafiseh, & GOLMOHAMMADZADEH, SHIVA. (2019). Preparation, characterization and evaluation the effects of microemulsion containing sesame oil on fibrinogen and factor VII level in animal model. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), 77(3 ), 199-206. SID. https://sid.ir/paper/366184/en

Vancouver: Copy

EBRAHIMI MAHMOUD, KARIMI MOHAMMAD, DEHGHANI FARANAK, Farhadian Nafiseh, GOLMOHAMMADZADEH SHIVA. Preparation, characterization and evaluation the effects of microemulsion containing sesame oil on fibrinogen and factor VII level in animal model. TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ)[Internet]. 2019;77(3 ):199-206. Available from: https://sid.ir/paper/366184/en

IEEE: Copy

MAHMOUD EBRAHIMI, MOHAMMAD KARIMI, FARANAK DEHGHANI, Nafiseh Farhadian, and SHIVA GOLMOHAMMADZADEH, “Preparation, characterization and evaluation the effects of microemulsion containing sesame oil on fibrinogen and factor VII level in animal model,” TEHRAN UNIVERSITY MEDICAL JOURNAL (TUMJ), vol. 77, no. 3 , pp. 199–206, 2019, [Online]. Available: https://sid.ir/paper/366184/en

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