The Effect of Low Doses of Memantine on Serum Levels of Inflammatory Mediators in Methadone-Dependent Rats

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Mortazavi Bahareh; TAHERGORABI ZOYA; MEHRPOUR OMID; MOODI MITRA

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Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2019 | Volume:37 | Issue:523 Page(s): 392-399

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Title

The Effect of Low Doses of Memantine on Serum Levels of Inflammatory Mediators in Methadone-Dependent Rats

Author(s)

Mortazavi Bahareh | TAHERGORABI ZOYA | MEHRPOUR OMID | MOODI MITRA | Issue Writer Certificate

Keywords

MethadoneQ2

Inflammation mediatorsQ1

MemantineQ1

RatQ2

Abstract

Background: Opioid abuse is a major and challenging public health problem with a broad range of physical, mental, and psychiatric consequences worldwide. This study was designed to evaluate the effect of low doses of Memantine on serum levels of inflammatory mediators in Methadone-dependent Rats. Methods: This study was performed on 40 male wistar Rats weighing 300-350 grams in four groups (n = 10). The Rats were weighed at the beginning and the end of the study, and fasting blood glucose was measured by glucometer. Within 10 days, one group received intraperitoneal Methadone 5 mg/kg, two groups received Memantine 30 minutes before Methadone injection subcutaneously 1 and 2 mg/kg, respectively, and the last group received normal saline. At the end, Rats were sacrificed, and serum levels of high-sensitivity C-reactive protein (hsCRP), nuclear factor kappa B (NF-kB), tumor necrosis factor-α (TNF-α ), interleukin 6 (IL-6), and lipid profiles were measured. Findings: Thera was a significant difference between the four groups in the mean level of NFκ β (P = 0. 040) and hsCPR (P = 0. 020). There was a significant difference between lipid profiles in mean levels of low-density lipoprotein (LDL) (P < 0. 001), high-density lipoprotein (HDL) (P = 0. 040), and triglyceride (P = 0. 030). Conclusion: Our results showed that dependence on Methadone affects the level of inflammatory mediators, and Memantine could reduce these levels. Therefore, Memantine can be considered as a new anti-addiction approach in the treatment of opioid-dependent patients who are on Methadone maintenance treatment (MMT).

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APA: Copy

Mortazavi, Bahareh, TAHERGORABI, ZOYA, MEHRPOUR, OMID, & MOODI, MITRA. (2019). The Effect of Low Doses of Memantine on Serum Levels of Inflammatory Mediators in Methadone-Dependent Rats. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 37(523 ), 392-399. SID. https://sid.ir/paper/366536/en

Vancouver: Copy

Mortazavi Bahareh, TAHERGORABI ZOYA, MEHRPOUR OMID, MOODI MITRA. The Effect of Low Doses of Memantine on Serum Levels of Inflammatory Mediators in Methadone-Dependent Rats. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2019;37(523 ):392-399. Available from: https://sid.ir/paper/366536/en

IEEE: Copy

Bahareh Mortazavi, ZOYA TAHERGORABI, OMID MEHRPOUR, and MITRA MOODI, “The Effect of Low Doses of Memantine on Serum Levels of Inflammatory Mediators in Methadone-Dependent Rats,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 37, no. 523 , pp. 392–399, 2019, [Online]. Available: https://sid.ir/paper/366536/en

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