STUDY OF SPERM PARAMETERS AND SPERM FERTILITY IN MICE WERE EXPOSED TO TAMOXIFEN DURING EMBRYONIC DEVELOPMENT

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SOLEIMANIRAD JAFAR; ROSHANGAR LEILA; ABOUZARIPOUR MORTEZA; DANESHI ERFAN

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2017 | Volume:25 | Issue:2 Page(s): 101-110

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Title

STUDY OF SPERM PARAMETERS AND SPERM FERTILITY IN MICE WERE EXPOSED TO TAMOXIFEN DURING EMBRYONIC DEVELOPMENT

Author(s)

SOLEIMANIRAD JAFAR | ROSHANGAR LEILA | ABOUZARIPOUR MORTEZA | DANESHI ERFAN | Issue Writer Certificate

Keywords

TAMOXIFENQ2

FERTILITYQ2

PARAMETERQ1

EMBRYONICQ3

DEVELOPMENTQ2

Abstract

Introduction: TAMOXIFEN is steroidal drug, which mainly treats breast cancer and also used to stimulate ovulation. The purpose of the present study was the evaluation of sperm PARAMETERs and FERTILITY of mice whose mothers had received TAMOXIFEN during pregnancy.Methods: In this study, 30 female and 15 male mice of NMRI were selected for mating. After mating female mice were randomly divided into two groups, the first group (control) and second group (experimental). All of which contained 15 mice. From the day 13th day of pregnancy, experimental group has received TAMOXIFEN with the dosage of 5 mg/kg for 7 days. After childbirth of the mated mice, male infants were selected. After reaching the age of puberty (6-8 Weeks), adult mice were sacrificed by the cervical dislocation. After take sperm, sperm PARAMETERs (count, normality and motility), and sperm FERTILITY was performed. In this study SPSS software and statistical t-test was used (p<0.001).Results: Studies showed that sperm PARAMETERs and sperm fertilization were significantly different. The number of sperm in the control group was 83.50±28.20 million, and in the experimental group was 60±14.14 million. There was a decrease in average sperm count in the experimental group compared with the control group (p<0.001). Our findings from in vitro fertilization culture media showed that embryos formation and oocyte disruption between control and experimental groups significantly different (p<0.001).Conclusion: The results showed that TAMOXIFEN exposure during DEVELOPMENT can cause histological changes in the seminiferous tubules, which can lead to infertility.

Cites

Effect of Oxaliplatin on sperm parameters of 60 days old offspring during pre-pregnancy, pregnancy and lactation period in mice

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APA: Copy

SOLEIMANIRAD, JAFAR, ROSHANGAR, LEILA, ABOUZARIPOUR, MORTEZA, & DANESHI, ERFAN. (2017). STUDY OF SPERM PARAMETERS AND SPERM FERTILITY IN MICE WERE EXPOSED TO TAMOXIFEN DURING EMBRYONIC DEVELOPMENT. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 25(2), 101-110. SID. https://sid.ir/paper/36657/en

Vancouver: Copy

SOLEIMANIRAD JAFAR, ROSHANGAR LEILA, ABOUZARIPOUR MORTEZA, DANESHI ERFAN. STUDY OF SPERM PARAMETERS AND SPERM FERTILITY IN MICE WERE EXPOSED TO TAMOXIFEN DURING EMBRYONIC DEVELOPMENT. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(2):101-110. Available from: https://sid.ir/paper/36657/en

IEEE: Copy

JAFAR SOLEIMANIRAD, LEILA ROSHANGAR, MORTEZA ABOUZARIPOUR, and ERFAN DANESHI, “STUDY OF SPERM PARAMETERS AND SPERM FERTILITY IN MICE WERE EXPOSED TO TAMOXIFEN DURING EMBRYONIC DEVELOPMENT,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 2, pp. 101–110, 2017, [Online]. Available: https://sid.ir/paper/36657/en

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