EFFICACY OF KETOCONAZOLE IN PREVENTION OF ACUTE RESPIRATORY DISTRESS SYNDROME

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SOLTANI H.; MOSHTAGHIOUN S.H.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2001 | Volume:9 | Issue:2 Page(s): 49-55

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Information Journal Paper

Title

EFFICACY OF KETOCONAZOLE IN PREVENTION OF ACUTE RESPIRATORY DISTRESS SYNDROME

Author(s)

SOLTANI H. | MOSHTAGHIOUN S.H. | Issue Writer Certificate

Keywords

KETOCONAZOLEQ3

RESPIRATORY DISTRESS SYNDROMQ3

PREVENTIONQ3

Abstract

Respivatory Distress syndrome (ARDS) has not proven pharmacologic treatment. It has been shown that Tromboxane A2 is one of the main mediator in ARDS . KETOCONAZOLE probably inhibits the synthesis of this mediator and prevents ARDS in patients with ARDS Risk Factors. This study was conducted to determine the efficacy of KETOCONAZOLE in PREVENTION of ARDS in patients with risk factors. 46 consecutive patients with risk factors including sepsis, fat emboli, pulmonary aspiration and lung contusion randomly recieved either ketoconazol (400mg) or placebo via naso gastric tube in a double blind fashion. Then, the patients were followed for the development of ARDS. Prophylaxis with ketoconazol resulted in significant reduction (P value < 0.04) in frequency of ARDS in sepsis group but not all of patients compared with placebo group (16% vs 58%). A statistically significant reduction in mortality was not achieved. This study supports the use of ketoconazol in sepsis patients as prophilaxis.

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APA: Copy

SOLTANI, H., & MOSHTAGHIOUN, S.H.. (2001). EFFICACY OF KETOCONAZOLE IN PREVENTION OF ACUTE RESPIRATORY DISTRESS SYNDROME . JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 9(2), 49-55. SID. https://sid.ir/paper/36666/en

Vancouver: Copy

SOLTANI H., MOSHTAGHIOUN S.H.. EFFICACY OF KETOCONAZOLE IN PREVENTION OF ACUTE RESPIRATORY DISTRESS SYNDROME . JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2001;9(2):49-55. Available from: https://sid.ir/paper/36666/en

IEEE: Copy

H. SOLTANI, and S.H. MOSHTAGHIOUN, “EFFICACY OF KETOCONAZOLE IN PREVENTION OF ACUTE RESPIRATORY DISTRESS SYNDROME ,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 9, no. 2, pp. 49–55, 2001, [Online]. Available: https://sid.ir/paper/36666/en

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