GLUCOCORTICOID-INDUCED APOPTOSIS OF THYMOCYTES IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DOUSTAR Y.; GHAZI JAHANI R.; NESHAT GHARAMALEKI M.; HASHEMI M.; MALAYERI H.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch Year:2005 | Volume:14 | Issue:2 Page(s): 81-88

Download Full-Text

Persian Verion

View:

1,000

Download:

Cites:

Information Journal Paper

Title

GLUCOCORTICOID-INDUCED APOPTOSIS OF THYMOCYTES IN RATS

Author(s)

Keywords

APOPTOSISQ3

THYMOCYTEQ2

CORTICOSTEROIDQ4

Abstract

Background: APOPTOSIS or cell suicide or programmed cell death (PCD) is an important mechanism in both development and homeostasis in adult tissues for the removal of either superfluous, infected, transformed or damaged cell by activation of an intrinsic suicide program. Signals may either suppress or promote APOPTOSIS. Glucocorticoids are well-known signals promoting APOPTOSIS in rat THYMOCYTEs.Dexamethasone, as a prototype of CORTICOSTEROIDs, may induce indigenous endonuclease-mediated cell APOPTOSIS. Therefore we apply dexamethasone as a synthetic glucocorticoid in rats. The aim of the present study were to evaluate the effects of dexamethasone on rat cells, study light and electron microscopic changes and of course, demonstrate the relationship between doses of drug and extent of APOPTOSIS.Materials and methods: We organized treatment group consisting of four sub-groups (each including 5 rats), naming T-a, T-b, T-c and T-d, each received dexamethasone intraperitoneally at the dosage of 0.5, 1.5, 2.5 and 3.5 mg/kg, respectively.Similarly, four control sub groups were assigned. Six hours after administration, the thymus gland of all treatment and control group rats were ectomized and investigated by light and electronic microscopes.Results: Apoptotic bodies appeared as round or oval cytoplasmic masses with or without contained basophilic nuclear material and well defined cresentric clamps of chromatin in light microscope, weheras, electronic microscope studies demonstrated the peripheral nuclear chromatin form aggregate of osmiophilic granules, which separated from the fibrillar core and irregular cell outline nuclear fragments and whirling endoplasmic reticulum. There was a positive association between drug dosage and severity of APOPTOSIS.Conclusion: Results have revealed that CORTICOSTEROIDs in therapeutic and over-dose excite and stimulate DNA fragmentation in THYMOCYTEs. CORTICOSTEROID-induced death of THYMOCYTEs is recognized as a calcium dependent process.

Cites

No record.

References

No record.

Cite

APA: Copy

DOUSTAR, Y., GHAZI JAHANI, R., NESHAT GHARAMALEKI, M., HASHEMI, M., & MALAYERI, H.. (2005). GLUCOCORTICOID-INDUCED APOPTOSIS OF THYMOCYTES IN RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 14(2), 81-88. SID. https://sid.ir/paper/367073/en

Vancouver: Copy

DOUSTAR Y., GHAZI JAHANI R., NESHAT GHARAMALEKI M., HASHEMI M., MALAYERI H.. GLUCOCORTICOID-INDUCED APOPTOSIS OF THYMOCYTES IN RATS. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2005;14(2):81-88. Available from: https://sid.ir/paper/367073/en

IEEE: Copy

Y. DOUSTAR, R. GHAZI JAHANI, M. NESHAT GHARAMALEKI, M. HASHEMI, and H. MALAYERI, “GLUCOCORTICOID-INDUCED APOPTOSIS OF THYMOCYTES IN RATS,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 14, no. 2, pp. 81–88, 2005, [Online]. Available: https://sid.ir/paper/367073/en

Related Journal Papers