Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats

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ZARDOOZ HOMEIRA; Sadeghi mahalli Forouzan; SALIMI MINA

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Title

Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats

Author(s)

ZARDOOZ HOMEIRA | Sadeghi mahalli Forouzan | SALIMI MINA | Issue Writer Certificate

Keywords

early life stressQ1

psychological stressQ1

physical stressQ1

Langerhans isletsQ2

Abstract

Background and purpose: Stressful events in early-life induce metabolic disorders in adolescence. The aim of this study was to investigate the effect of early-life stress on number or area of Langerhans islets in exposure to foot-shock and psychological stress in male rats. Materials and methods: The rats were divided into six groups: control (without stress), earlystress (stress at 2 weeks of age), pubertal-foot shock (at 8-10 weeks of age), pubertal-psychological stress (psychological stress at 8-10 weeks of age), early-stress + pubertal-foot shock (stress at 2 weeks and footshock at 8-10 weeks of age), early-stress + pubertal-psychological stress (early-stress at 2 weeks and psychological stress at 8-10 weeks of age). Stress was induced for five consecutive days (twice daily). At the end of the experiment, following anesthesia with pentobarbital, the rats were decapitated and dissected to remove pancreas tissue to measure the number and area of islets. Results: Early-life and pubertal stresses alone did not change the number or area of islets. Compared to other interventions, early-life psychological-stress could considerably change the number or area of pancreatic islets. Conclusion: early life stress predisposes the organism to morphological changes in endocrine pancreas as an increase in Langerhans islets number or area in exposure to stress later in life.

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APA: Copy

ZARDOOZ, HOMEIRA, Sadeghi mahalli, Forouzan, & SALIMI, MINA. (2020). Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 29(182 ), 91-98. SID. https://sid.ir/paper/367121/en

Vancouver: Copy

ZARDOOZ HOMEIRA, Sadeghi mahalli Forouzan, SALIMI MINA. Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;29(182 ):91-98. Available from: https://sid.ir/paper/367121/en

IEEE: Copy

HOMEIRA ZARDOOZ, Forouzan Sadeghi mahalli, and MINA SALIMI, “Histological Evaluation of Pancreas Following Early Life Stress in Exposure to Pubertal Stress in Male Rats,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 29, no. 182 , pp. 91–98, 2020, [Online]. Available: https://sid.ir/paper/367121/en

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