The effect of miR-34a replacement in the proliferation inhibition of cancerous cell line of esophagus

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Moshfegh Parvin; ALETAHA MANSOOR; BARADARAN BEHZAD

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Journal: Razi Journal of Medical Sciences Year:2019 | Volume:26 | Issue:9 Page(s): 29-38

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Information Journal Paper

Title

The effect of miR-34a replacement in the proliferation inhibition of cancerous cell line of esophagus

Author(s)

Moshfegh Parvin | ALETAHA MANSOOR | BARADARAN BEHZAD | Issue Writer Certificate

Keywords

Esophageal cancerQ3

miRNA-34aQ1

TE-8Q1

VimentinQ1

Abstract

Background: Because of its malignancy and poor prognosis, Esophageal cancer is the sixth cause of death around the world. MiR-34a is a tumor suppressor. The miRNA-34 family is involved in suppressing the tumor and oncogenic pathways in some cancers. The purpose of this research is to determine the changes in the expression of the Vimentin gene after the replacement of miR-34a, on the other hand the effect of replacing this micro-RNA on cell proliferation is determined. Methods: After cultivating the TE-8 cell line, miR-34a was replaced in Esophageal cancer cells and after miR-34a replacement, Vimentin gene expression was evaluated using qRT-PCR method. Cell proliferation in the TE-8 cell line was evaluated in effective time and dose after the replacement of mir-34a by the MTT method. Results: Replacing miR-34a in the TE-8 cell line significantly reduced the expression of Vimentin (p<0. 0001). Mir-34a could (at an effective dose) within 24 hours significantly reduce cell proliferation (p<0. 0001). Conclusion: Possibly, the replacement of miR-34a could have a therapeutic role in Esophageal cancer.

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References

Circulating microRNAs: valuable biomarkers in biological fluids

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APA: Copy

Moshfegh, Parvin, ALETAHA, MANSOOR, & BARADARAN, BEHZAD. (2019). The effect of miR-34a replacement in the proliferation inhibition of cancerous cell line of esophagus. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), 26(9 ), 29-38. SID. https://sid.ir/paper/367444/en

Vancouver: Copy

Moshfegh Parvin, ALETAHA MANSOOR, BARADARAN BEHZAD. The effect of miR-34a replacement in the proliferation inhibition of cancerous cell line of esophagus. RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES)[Internet]. 2019;26(9 ):29-38. Available from: https://sid.ir/paper/367444/en

IEEE: Copy

Parvin Moshfegh, MANSOOR ALETAHA, and BEHZAD BARADARAN, “The effect of miR-34a replacement in the proliferation inhibition of cancerous cell line of esophagus,” RAZI JOURNAL OF MEDICAL SCIENCES (JOURNAL OF IRAN UNIVERSITY OF MEDICAL SCIENCES), vol. 26, no. 9 , pp. 29–38, 2019, [Online]. Available: https://sid.ir/paper/367444/en

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