Effects of Parathion Toxin on Glutamate Dehydrogenase Enzyme Activity and Diabetes Induction

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JAMSHIDI HAMID REZA; EBRAHIMI ELHAM

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Journal: TOLOO-E-BEHDASHT Year:2019 | Volume:18 | Issue:1 (73) Page(s): 83-93

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Title

Effects of Parathion Toxin on Glutamate Dehydrogenase Enzyme Activity and Diabetes Induction

Author(s)

JAMSHIDI HAMID REZA | EBRAHIMI ELHAM | Issue Writer Certificate

Keywords

ParathionQ1

Glutamate dehydrogenaseQ1

PancreasQ1

RatQ3

Abstract

Introduction: The main propose of this study was to determine the effect of Rathion/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">PaRathion on activity of Glutamate dehydrogenase (GDH) as a key enzyme in second phase secretion of insulin and to determine serum glucose levels in Rats. Methods: To conduct the study, 35 Rats were randomly divided into five groups (n=7). The serum glucose level of each group was measured and the total average was calculated with a glucometer. The experimental groups (groups 1, 2, 3, 4) received 0. 5, 1, 1. 5, and 2 mg/kg of Rathion/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">PaRathion pesticide via IP injection; whereas, the control group received no treatment. All Rats were kept in similar condition. Serum glucose levels of Rats were measured 24h after the final injection. Glutamate dehydrogenase (GDH) activity in Rat’ s Pancreas was measured by GDH activity assay kit and using a spectrophotometer at 570nm. Results: The levels of glucose in treatment groups significantly increased compared with the control group (P<0. 01). The levels of GDH activity in Rats increased after receiving 1. 5 and 2 mg/kg of Rathion/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">PaRathion pesticides compared with the control group (P<0. 01, p<0. 05). Conclusion: Regarding the results, Rathion/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">PaRathion affects the GDH enzyme in the pancreatic islets and leads to insufficient secretion of insulin. Although insulin was increased and increased the intermediates of Krebs cycle, the Rate of insulin secretion was not so high to overcome the increase of glucose caused by Rathion/fa?page=1&sort=1&ftyp=all&fgrp=all&fyrs=all" target="_blank">PaRathion organophosphate.

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APA: Copy

JAMSHIDI, HAMID REZA, & EBRAHIMI, ELHAM. (2019). Effects of Parathion Toxin on Glutamate Dehydrogenase Enzyme Activity and Diabetes Induction. TOLOO-E-BEHDASHT, 18(1 (73) ), 83-93. SID. https://sid.ir/paper/367565/en

Vancouver: Copy

JAMSHIDI HAMID REZA, EBRAHIMI ELHAM. Effects of Parathion Toxin on Glutamate Dehydrogenase Enzyme Activity and Diabetes Induction. TOLOO-E-BEHDASHT[Internet]. 2019;18(1 (73) ):83-93. Available from: https://sid.ir/paper/367565/en

IEEE: Copy

HAMID REZA JAMSHIDI, and ELHAM EBRAHIMI, “Effects of Parathion Toxin on Glutamate Dehydrogenase Enzyme Activity and Diabetes Induction,” TOLOO-E-BEHDASHT, vol. 18, no. 1 (73) , pp. 83–93, 2019, [Online]. Available: https://sid.ir/paper/367565/en

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