Evaluation of Cardiac Hemodynamic Parameters Following Ischemia-Reperfusion Injury in a Rat Model of Polycystic Ovary Syndrome

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

NOROOZZADEH MAHSA; SARAHIAN NAHID; BIDHENDI YARANDI RAZIEH; RAMEZANI TEHRANI FAHIMEH

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Mazandaran University of Medical Sciences Year:2020 | Volume:30 | Issue:184 Page(s): 73-85

Download Full-Text

Persian Verion

View:

793

Download:

Cites:

Information Journal Paper

Title

Evaluation of Cardiac Hemodynamic Parameters Following Ischemia-Reperfusion Injury in a Rat Model of Polycystic Ovary Syndrome

Author(s)

NOROOZZADEH MAHSA | SARAHIAN NAHID | BIDHENDI YARANDI RAZIEH | RAMEZANI TEHRANI FAHIMEH | Issue Writer Certificate

Keywords

cardiac functionQ2

ischemia/reperfusion injuryQ1

polycystic ovary syndromeQ2

ratQ2

Abstract

Introduction: polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women during reproductive ages. This syndrome is associated with disruption of sex hormone levels. Studies have shown that endurance of the heart to ischemia-reperfusion (I/R) injury can be affected by sex hormones. In the present study, the rate of cardiac tolerance against I/R injury in the PCOS rat model was compared with normal (control) rats. Materials and Methods: The rats were randomly divided into two groups; PCOS and control (n=8 per group). The hearts were isolated in Langendorff isolated heart system. Cardiac perfusion was performed in a retrograde flow in the aorta at constant pressure (75 mmHg) by Krebs-Henslit buffer. A pressure (5-10 mmHg) was put to the left ventricle, using an intraventricular balloon, to measure the hemodynamic parameters of the heart. Cardiac signals were recorded while being transmitted through the catheter to the Powerbull system. Results: Before I/R, the values for cardiac hemodynamic parameters including HR, LVDP, RPP and ± dp/dt, increased in the rat model of PCOS compared to controls, although these increases were not statistically significant (P>0. 05). These parameters had decreasing trends after I/R in PCOS rats compared to controls which were not statistically significant (P>0. 05). Conclusion: Cardiac resistance to I/R injury was found to be similar in both PCOS and control animals, which could be due to the cardioprotective role of sex hormones such as estrogens.

Cites

No record.

References

No record.

Cite

APA: Copy

NOROOZZADEH, MAHSA, SARAHIAN, NAHID, BIDHENDI YARANDI, RAZIEH, & RAMEZANI TEHRANI, FAHIMEH. (2020). Evaluation of Cardiac Hemodynamic Parameters Following Ischemia-Reperfusion Injury in a Rat Model of Polycystic Ovary Syndrome. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, 30(184 ), 73-85. SID. https://sid.ir/paper/367622/en

Vancouver: Copy

NOROOZZADEH MAHSA, SARAHIAN NAHID, BIDHENDI YARANDI RAZIEH, RAMEZANI TEHRANI FAHIMEH. Evaluation of Cardiac Hemodynamic Parameters Following Ischemia-Reperfusion Injury in a Rat Model of Polycystic Ovary Syndrome. JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;30(184 ):73-85. Available from: https://sid.ir/paper/367622/en

IEEE: Copy

MAHSA NOROOZZADEH, NAHID SARAHIAN, RAZIEH BIDHENDI YARANDI, and FAHIMEH RAMEZANI TEHRANI, “Evaluation of Cardiac Hemodynamic Parameters Following Ischemia-Reperfusion Injury in a Rat Model of Polycystic Ovary Syndrome,” JOURNAL OF MAZANDARAN UNIVERSITY OF MEDICAL SCIENCES, vol. 30, no. 184 , pp. 73–85, 2020, [Online]. Available: https://sid.ir/paper/367622/en

Related Journal Papers