Effect of Hypothermia by JZL-184 on Muscle Strength and Sensory-Motor Dysfunction in Permanent Middle Cerebral Artery Ischemia Model in Male Mice

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

RAHMANI MOHAMMAD REZA; ALLAHTAVAKOLI MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2020 | Volume:28 | Issue:2 Page(s): 2351-2362

Download Full-Text

Persian Verion

View:

530

Download:

Cites:

Information Journal Paper

Title

Effect of Hypothermia by JZL-184 on Muscle Strength and Sensory-Motor Dysfunction in Permanent Middle Cerebral Artery Ischemia Model in Male Mice

Author(s)

RAHMANI MOHAMMAD REZA | ALLAHTAVAKOLI MOHAMMAD | Issue Writer Certificate

Keywords

StrokeQ2

JZL-184Q1

HypothermiaQ2

IschemiaQ2

Abstract

Introduction: Currently, there is no effective and comprehensive treatment for ischemic Stroke. There is strong clinical evidence for the benefits of Hypothermia in neuroprotection. Therefore, the present study aimed to determine the effect of mild non-invasive Hypothermia by JZL-184 on behavioral improvement in Stroke rats. Methods: This study was performed on 5 groups of male mice weighing 25-30 g. The groups were as follows: 1-Healthy group 2-Control group (Stroke) 3-Stroke + DMSO solvent 4-Stroke + Aspirin (40mg /kg) 5-Stroke + JZL-184 (16mg / kg) (n = 8 per group). The drugs were injected intraperitoneally immediately after the Stroke. At the times before (time zero) and at 5, 24 and 48 h after Stroke induction, body temperature, behavioral testing, including muscle strength and sensory-motor dysfunction were measured. Data were analyzed by SPSS version 18 software and Two-way ANOVA test (P ≤ 0. 05). Results: JZL-184 decreased body temperature at 5, 24 and 48 hours compared to intact and control groups (p <0. 001). Injection JZL-184 and Aspirin improved muscle strength and sensory-motor function (p <0. 001) compared to the control group. Aspirin also improved behavioral tests compared to the control group (p <0. 01), but did not show any effect on the body temperature compared to the intact group at time 48. Only in JZL-184 group, the behavioral tests score was similar to the intact group at the 48 h after Stroke. Conclusion: JZL-184 may have been able to improve neuronal function by Hypothermia induced by the agonist effects of cannabinoid receptor 1 (CB1), thereby improving muscle strength and sensory-motor function after cerebral Ischemia.

Cites

No record.

References

Cite

APA: Copy

RAHMANI, MOHAMMAD REZA, & ALLAHTAVAKOLI, MOHAMMAD. (2020). Effect of Hypothermia by JZL-184 on Muscle Strength and Sensory-Motor Dysfunction in Permanent Middle Cerebral Artery Ischemia Model in Male Mice. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 28(2 ), 2351-2362. SID. https://sid.ir/paper/36771/en

Vancouver: Copy

RAHMANI MOHAMMAD REZA, ALLAHTAVAKOLI MOHAMMAD. Effect of Hypothermia by JZL-184 on Muscle Strength and Sensory-Motor Dysfunction in Permanent Middle Cerebral Artery Ischemia Model in Male Mice. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;28(2 ):2351-2362. Available from: https://sid.ir/paper/36771/en

IEEE: Copy

MOHAMMAD REZA RAHMANI, and MOHAMMAD ALLAHTAVAKOLI, “Effect of Hypothermia by JZL-184 on Muscle Strength and Sensory-Motor Dysfunction in Permanent Middle Cerebral Artery Ischemia Model in Male Mice,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 28, no. 2 , pp. 2351–2362, 2020, [Online]. Available: https://sid.ir/paper/36771/en

Related Journal Papers