EFFECTS OF SYSTEMIC AND INTRA-HIPPOCAMPAL INJECTIONS OF CYCLOHEXIMIDE ON THE LATE RECONSOLIDATION OF FEAR-BASED MEMORY IN RATS

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MALEKLOO ROYA; RASHIDY POUR ALI; VAFAEI ABBAS ALI; SAMENI HAMID REZA

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Journal: Koomesh Year:2015 | Volume:16 | Issue:3 (55) Page(s): 433-442

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Title

EFFECTS OF SYSTEMIC AND INTRA-HIPPOCAMPAL INJECTIONS OF CYCLOHEXIMIDE ON THE LATE RECONSOLIDATION OF FEAR-BASED MEMORY IN RATS

Author(s)

MALEKLOO ROYA | RASHIDY POUR ALI | VAFAEI ABBAS ALI | SAMENI HAMID REZA | Issue Writer Certificate

Keywords

PROTEIN SYNTHESISQ2

CYCLOHEXIMIDEQ2

DORSAL HIPPOCAMPUSQ2

LATE MEMORY RECONSOLIDATIONQ2

PASSIVE AVOIDANCE TASKQ2

Abstract

Introduction: Reactivation of a stabilized memory induces a second wave of consolidation process which is now called as reconsolidation. Recently, a late consolidation process was proposed, suggesting that memory after learning within a delayed time window was labile. This late memory consolidation needs PROTEIN SYNTHESIS in the hippocampus. The aim of this study was to test whether the re-stabilized memory after reactivation also requires a late-phase PROTEIN SYNTHESIS in the hippocampus. We also investigated whether memories become increasingly resistant to disruption with age.Materials and Methods: Male Wistar rats were trained in a one trial PASSIVE AVOIDANCE TASK (1mA, 3s). In the first experiment, CYCLOHEXIMIDE (CYC, 2.8 mg/kg, i.p.) administrated 15 minutes before the memory reactivation and also 3, 6, 12 and 24 hours after the memory reactivation. In the second experiment, the same dose of CYC administrated to rats with memory age of 7, 14, 28 or 56 days. In the third experiment, CYC administrated (4 mg or 8mg/ml) into hippocampus. In the last experiment, CYC administrated (8mg/ml) into hippocampus of rats with memory age of 7, 14, 28 or 56 days. In all experiments, memory test was done 2 and 7 days after memory reactivation.Results: Results indicated that systemic administration of CYC only 12h after memory reactivation significantly impaired memory retention. With increasing the age of memory, no effect of CYC was found. This impairing effect also was found when CYC was injected into hippocampus. This impairing effect also was found on memory age with 7 days.Conclusion: Our findings indicate that PROTEIN SYNTHESIS, particularly in the hippocampus, plays an important role in the LATE MEMORY RECONSOLIDATION and with increasing the age of memories, they become resistant to disruption.

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APA: Copy

MALEKLOO, ROYA, RASHIDY POUR, ALI, VAFAEI, ABBAS ALI, & SAMENI, HAMID REZA. (2015). EFFECTS OF SYSTEMIC AND INTRA-HIPPOCAMPAL INJECTIONS OF CYCLOHEXIMIDE ON THE LATE RECONSOLIDATION OF FEAR-BASED MEMORY IN RATS. KOOMESH, 16(3 (55)), 433-442. SID. https://sid.ir/paper/36805/en

Vancouver: Copy

MALEKLOO ROYA, RASHIDY POUR ALI, VAFAEI ABBAS ALI, SAMENI HAMID REZA. EFFECTS OF SYSTEMIC AND INTRA-HIPPOCAMPAL INJECTIONS OF CYCLOHEXIMIDE ON THE LATE RECONSOLIDATION OF FEAR-BASED MEMORY IN RATS. KOOMESH[Internet]. 2015;16(3 (55)):433-442. Available from: https://sid.ir/paper/36805/en

IEEE: Copy

ROYA MALEKLOO, ALI RASHIDY POUR, ABBAS ALI VAFAEI, and HAMID REZA SAMENI, “EFFECTS OF SYSTEMIC AND INTRA-HIPPOCAMPAL INJECTIONS OF CYCLOHEXIMIDE ON THE LATE RECONSOLIDATION OF FEAR-BASED MEMORY IN RATS,” KOOMESH, vol. 16, no. 3 (55), pp. 433–442, 2015, [Online]. Available: https://sid.ir/paper/36805/en

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