REWIVE ARTICLE; OREXIN (HYPOCRETIN): A MULTI-FUNCTIONAL HYPOTHALAMIC PEPTIDE

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SHABANI MOHAMMAD; MOHAMMAD ZADEH MOHAMMAD; AZHDARI ZARMEHRI HASSAN

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Paper Information

Journal: Koomesh Year:2014 | Volume:15 | Issue:3 (51) Page(s): 275-281

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Information Journal Paper

Title

REWIVE ARTICLE; OREXIN (HYPOCRETIN): A MULTI-FUNCTIONAL HYPOTHALAMIC PEPTIDE

Author(s)

SHABANI MOHAMMAD | MOHAMMAD ZADEH MOHAMMAD | AZHDARI ZARMEHRI HASSAN | Issue Writer Certificate

Keywords

OREXIN (HYPOCRETIN)Q2

HYPOTHALAMIC PEPTIDEQ2

REWARD SYSTEMQ2

OBESITYQ2

SLEEP DISORDERQ2

ADDICTIONQ2

Abstract

Hypocretins/orexins are novel hypothalamic neuropeptides involved in various hypothalamic mechanisms, such as energy homeostasis and neuroendocrine function. Orexins A (33 amino acids) and B (28 amino acids) are derived from a single pre-pro-orexin polypeptide. Physiological studies over the last ten years have implicated orexin signaling plays a central role in a variety of important biological processes. There is a clear evidence for defects in orexin signaling being involved in OBESITY and diabetes, narcolepsy, panic anxiety disorder and drug ADDICTION. Therefore, this system may be a potentially important therapeutic target for treatment of SLEEP DISORDER, OBESITY, emotional stress, and ADDICTION. In addtion, it has been well known that orexin-A elicits analgesia. Thus, there is a considerable interest in the drug industry in the development of potent compounds for the manipulation of orexin signaling. Therefore, This a review about recent progress in understanding orexin system.

Cites

ADMINISTRATION OF OREXIN RECEPTOR 1 ANTAGONIST INTO THE ROSTRAL VENTROMEDIAL MEDULLA INCREASED SWIM STRESS-INDUCED ANTINOCICEPTION IN RAT

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APA: Copy

SHABANI, MOHAMMAD, MOHAMMAD ZADEH, MOHAMMAD, & AZHDARI ZARMEHRI, HASSAN. (2014). REWIVE ARTICLE; OREXIN (HYPOCRETIN): A MULTI-FUNCTIONAL HYPOTHALAMIC PEPTIDE. KOOMESH, 15(3 (51)), 275-281. SID. https://sid.ir/paper/36823/en

Vancouver: Copy

SHABANI MOHAMMAD, MOHAMMAD ZADEH MOHAMMAD, AZHDARI ZARMEHRI HASSAN. REWIVE ARTICLE; OREXIN (HYPOCRETIN): A MULTI-FUNCTIONAL HYPOTHALAMIC PEPTIDE. KOOMESH[Internet]. 2014;15(3 (51)):275-281. Available from: https://sid.ir/paper/36823/en

IEEE: Copy

MOHAMMAD SHABANI, MOHAMMAD MOHAMMAD ZADEH, and HASSAN AZHDARI ZARMEHRI, “REWIVE ARTICLE; OREXIN (HYPOCRETIN): A MULTI-FUNCTIONAL HYPOTHALAMIC PEPTIDE,” KOOMESH, vol. 15, no. 3 (51), pp. 275–281, 2014, [Online]. Available: https://sid.ir/paper/36823/en

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