INHIBITORY EFFECT OF LUTEOLIN ON MKN-45 TUMORG GASTRIC CELLS: THE ROLE OF NUCLEOSIDE-DIPHOSPHATE KINASES, COFILIN AND ACTIN PROTEINS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

TAHMASEBI ZAHRA; MOHAMMAD AKHAVAN MAZIAR; TORABI SEPIDEH; ABBASI NASER; SARHADI ELHAM; HATAM NEJADIAN NASIM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Koomesh Year:2017 | Volume:19 | Issue:3 (67) Page(s): 611-618

Download Full-Text

Persian Verion

View:

1,074

Download:

Cites:

Information Journal Paper

Title

INHIBITORY EFFECT OF LUTEOLIN ON MKN-45 TUMORG GASTRIC CELLS: THE ROLE OF NUCLEOSIDE-DIPHOSPHATE KINASES, COFILIN AND ACTIN PROTEINS

Author(s)

Keywords

LUTEOLINQ2

STOMACH NEOPLASMSQ1

COFILINQ1

ACTINSQ1

NUCLEOSIDE-DIPHOSPHATE KINASEQ3

ELECTROPHORESISQ3

Abstract

Introduction: LUTEOLIN is an important plant extract. This shows anti-inflammatory, inhibition of cell growth, induction of apoptosis and inhibition of metastasis. Gastric cancer is one of the most common cancers in the world. Also metastasis is widespread in this kind of cancer and late diagnosis is a cause of patient's death. COFILIN, actin and NUCLEOSIDE-DIPHOSPHATE KINASEs (NDPK) are important in cell death and metastasis. In this study the effect of LUTEOLIN on MKN-45 gastric carcinoma cells was evaluated.Materials and Methods: At first the cells were cultured and then for 48 hours were cultured with the drug concentration. Then the cells where collected and their protein were extracted and analyzed using 2D ELECTROPHORESIS and separated on the basis of their molecular mass and PI. After that these samples were used for determine the amino acid sequence by MOLDI-TOF.Results: The growth rate of MKN-45 inhibited under influence of LUTEOLIN, this means increasing Apoptosis. Based on the results presented here by identification of protein spots by MOLDI-TOF mass spectrometry the expression of three protein COFILIN, actin and NDPK has been decreased by LUTEOLIN.Conclusion: It seems that the anti- tumoral effect of LUTEOLIN is expressed through three proteins COFILIN, actin and NDPK in gastric cancer cells.

Cites

No record.

References

Cite

APA: Copy

TAHMASEBI, ZAHRA, MOHAMMAD AKHAVAN, MAZIAR, TORABI, SEPIDEH, ABBASI, NASER, SARHADI, ELHAM, & HATAM NEJADIAN, NASIM. (2017). INHIBITORY EFFECT OF LUTEOLIN ON MKN-45 TUMORG GASTRIC CELLS: THE ROLE OF NUCLEOSIDE-DIPHOSPHATE KINASES, COFILIN AND ACTIN PROTEINS. KOOMESH, 19(3 (67)), 611-618. SID. https://sid.ir/paper/37067/en

Vancouver: Copy

TAHMASEBI ZAHRA, MOHAMMAD AKHAVAN MAZIAR, TORABI SEPIDEH, ABBASI NASER, SARHADI ELHAM, HATAM NEJADIAN NASIM. INHIBITORY EFFECT OF LUTEOLIN ON MKN-45 TUMORG GASTRIC CELLS: THE ROLE OF NUCLEOSIDE-DIPHOSPHATE KINASES, COFILIN AND ACTIN PROTEINS. KOOMESH[Internet]. 2017;19(3 (67)):611-618. Available from: https://sid.ir/paper/37067/en

IEEE: Copy

ZAHRA TAHMASEBI, MAZIAR MOHAMMAD AKHAVAN, SEPIDEH TORABI, NASER ABBASI, ELHAM SARHADI, and NASIM HATAM NEJADIAN, “INHIBITORY EFFECT OF LUTEOLIN ON MKN-45 TUMORG GASTRIC CELLS: THE ROLE OF NUCLEOSIDE-DIPHOSPHATE KINASES, COFILIN AND ACTIN PROTEINS,” KOOMESH, vol. 19, no. 3 (67), pp. 611–618, 2017, [Online]. Available: https://sid.ir/paper/37067/en

Related Journal Papers