Effect of Trigonella Foenum Graecum. L on Serum Profile in High Cholesterol Fed Rats and its Comparison with Atorvastatin

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Kassaee S.N.; KASSAEE S.M.

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Journal: Journal of Animal Research Year:2019 | Volume:32 | Issue:2 Page(s): 142-154

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Information Journal Paper

Title

Effect of Trigonella Foenum Graecum. L on Serum Profile in High Cholesterol Fed Rats and its Comparison with Atorvastatin

Author(s)

Kassaee S.N. | KASSAEE S.M. | Issue Writer Certificate

Keywords

Atorvastatin CalciumQ1

TrigonellaQ2

CholesterolQ2

LDLQ1

Abstract

Today, medicinal plants are in the focus of attention because of their roles in treatment of many diseases. The aim of this study was to determine the hypoCholesterolemic effect of Trigonella Foenum Graecum. L (Fenugreek) seeds powder and its comparison with atorvastatin on high Cholesterol diet fed rats. Forty male rats weighing 180– 200g were monitored for two weeks and then were randomly divided into four groups of 10 each: group1(fed with normal diet: ND), group2, fed with high Cholesterol diet, HCD(ND mixed with 2 Cholesterol+ 0. 5 cholic acid), group3( fed with HCD mixed with fenugreek seeds powder, 8 g/kg bw/day: HCD+FEN ), group4 (fed with HCD supplemented with aqueous emulsion of atorvastatin, 0. 5mg/kg bw/day, administered via oral feeding tube: HCD+Ator). After 6 weeks, the serum levels of triglyceride, total Cholesterol, high density lipoprotein Cholesterol (HDL-c), alanine aminotransferase (ALT) and aspartic aminotransferase (AST) and fasting blood sugar (FBS) were assayed. Low density lipoprotein Cholesterol (LDL-c) was estimated by Friedewald equation. In groups received atorvastatin and fenugreek, the serum levels of Cholesterol, triglyceride, LDL-c and VLDL-c, ALT and FBS decreased (P<0. 001) and serum level of HDL-c increased (P<0. 05) as compared to group HCD. Fenugreek has hypolipidemic and hypoglycemic activities in high Cholesterol diet fed rats and ameliroate high Cholesterol diet induced dyslipidemia. Fenugreek seeds powder has shown significantly less potent hypolipidemic and hypoglycemic activities than atorvastatin.

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APA: Copy

Kassaee, S.N., & KASSAEE, S.M.. (2019). Effect of Trigonella Foenum Graecum. L on Serum Profile in High Cholesterol Fed Rats and its Comparison with Atorvastatin. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), 32(2 ), 142-154. SID. https://sid.ir/paper/371207/en

Vancouver: Copy

Kassaee S.N., KASSAEE S.M.. Effect of Trigonella Foenum Graecum. L on Serum Profile in High Cholesterol Fed Rats and its Comparison with Atorvastatin. JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY)[Internet]. 2019;32(2 ):142-154. Available from: https://sid.ir/paper/371207/en

IEEE: Copy

S.N. Kassaee, and S.M. KASSAEE, “Effect of Trigonella Foenum Graecum. L on Serum Profile in High Cholesterol Fed Rats and its Comparison with Atorvastatin,” JOURNAL OF ANIMAL RESEARCH (IRANIAN JOURNAL OF BIOLOGY), vol. 32, no. 2 , pp. 142–154, 2019, [Online]. Available: https://sid.ir/paper/371207/en

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