Roles of Stem Cells in the Treatment of Multiple Sclerosis

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Ebrahimikia Yasaman; DARABI SHAHRAM; RAJAEI FARZAD; ABBASZADEH HOJJAT ALLAH

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Journal: Research in Medicine Year:2019 | Volume:43 | Issue:3 Page(s): 177-185

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Title

Roles of Stem Cells in the Treatment of Multiple Sclerosis

Author(s)

Ebrahimikia Yasaman | DARABI SHAHRAM | RAJAEI FARZAD | ABBASZADEH HOJJAT ALLAH | Issue Writer Certificate

Keywords

Stem cellsQ2

Multiple sclerosisQ2

OligodendrocyteQ1

Abstract

Background: Multiple sclerosis (MS) is an inflammatory disease of the central nervous system which is accompanied by demyelination of the nerves, axonal loss, and disability. The availability of multiple diseasemodifying medications with regulatory approval to treat Multiple sclerosis illustrates the substantial progress made in treating the disease. However, these drugs are only partially effective in preventing inflammatory tissue damage in the central nervous system and none of them directly promotes repair. The current treatments for MS largely comprise medications that are either immunomodulatory or immunosuppressive and are aimed at reducing the frequency and intensity of relapses. Recent studies have shown that cellular therapies are capable of repairing CNS neurons and can prevent inflammatory damage caused by the disease. Materials and Methods: A comprehensive review study was performed on MS, the etiologies, and treatment methods using the keywords including Stem cells, Multiple sclerosis, and Oligodendrocyte in valid medical databases, mainly PubMed. Among the collected papers, articles that were most relevant to the purposes of the study were selected and studied. Conclusion: Cell therapy is considered a promising potential treatment for Multiple sclerosis, perhaps particularly for the progressive form of the disease for which there is currently no useful treatment. Stem cells can be differentiated into nerve cells, including Oligodendrocytes, in the patient's body and help repair neuronal myelin. Thus, in the present article, we reviewed a variety of cellular resources and their characteristics for the treatment of MS.

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APA: Copy

Ebrahimikia, Yasaman, DARABI, SHAHRAM, RAJAEI, FARZAD, & ABBASZADEH, HOJJAT ALLAH. (2019). Roles of Stem Cells in the Treatment of Multiple Sclerosis. PAJOUHESH DAR PEZESHKI, 43(3 ), 177-185. SID. https://sid.ir/paper/371467/en

Vancouver: Copy

Ebrahimikia Yasaman, DARABI SHAHRAM, RAJAEI FARZAD, ABBASZADEH HOJJAT ALLAH. Roles of Stem Cells in the Treatment of Multiple Sclerosis. PAJOUHESH DAR PEZESHKI[Internet]. 2019;43(3 ):177-185. Available from: https://sid.ir/paper/371467/en

IEEE: Copy

Yasaman Ebrahimikia, SHAHRAM DARABI, FARZAD RAJAEI, and HOJJAT ALLAH ABBASZADEH, “Roles of Stem Cells in the Treatment of Multiple Sclerosis,” PAJOUHESH DAR PEZESHKI, vol. 43, no. 3 , pp. 177–185, 2019, [Online]. Available: https://sid.ir/paper/371467/en

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