Comparison of Apoptotic Effects of S14161 and Citrus limon Leaves Hydroalcoholic Extracts on Breast Cancer Cells MCF-7

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

Hoshmandi Kiavash; Gooraninejad Saad; HOVEIZI ELHAM; TABANDEH MOHAMMAD REZA

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF DEVELOPMENTAL BIOLOGY Year:2019 | Volume:11 | Issue:1 Page(s): 65-72

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

607

Download:

Cites:

Information Journal Paper

Title

Comparison of Apoptotic Effects of S14161 and Citrus limon Leaves Hydroalcoholic Extracts on Breast Cancer Cells MCF-7

Author(s)

Hoshmandi Kiavash | Gooraninejad Saad | HOVEIZI ELHAM | TABANDEH MOHAMMAD REZA | Issue Writer Certificate

Keywords

Small moleculeQ1

S14161Q1

Sour Lime ExtractQ1

MCF-7 Cell LineQ2

Abstract

Breast cancer is a multifactorial disease in which genetics, hormonal factors and the interaction between individuals and the environment contribute to it. In the present study, we try to compare the effect of lime leaves extract and S14161 Small molecule on apoptosis of MCF-7 breast cancer cells. Apoptotic effects of S14161 and hydroalcoholic extract of Lime leaves on MCF-7 cells were investigated using MTT method, the morphology of cells with acridine orange staining using the fluorescent microscope. The results showed that the S14161 and Lime leave extract decreases the survival rate and proliferation of MCF-7 cells in a time and dose-dependent manner. Based on the results of the MTT test, 10 μ M concentration of S14161 and 6 mM concentration of Lime extract was determined within 24 hours as IC50 concentration of MCF-7 cells. Comparison of Lime extract and S14161 showed that the amount of Small molecule cytotoxicity was higher than that of Lime leaves extract and there was a significant difference between survival percentage of cancer cells treated with S14161 and cells treated with lime leaves extracts on day 1, 3 and 5 (P <0. 05). Also, there were significant morphological changes such as shrinkage and increasing size of vacuoles, cytoplasmic loss, nucleus pigmentation and fragmentation of chromatin in treated cancer cells. The specific effect of this inhibitor on cell growth, as well as the lack of observation of toxic effects to high concentrations, has been described as a major strategy for treating breast cancers.

Cites

No record.

References

No record.

Cite

APA: Copy

Hoshmandi, Kiavash, Gooraninejad, Saad, HOVEIZI, ELHAM, & TABANDEH, MOHAMMAD REZA. (2019). Comparison of Apoptotic Effects of S14161 and Citrus limon Leaves Hydroalcoholic Extracts on Breast Cancer Cells MCF-7. JOURNAL OF DEVELOPMENTAL BIOLOGY, 11(1 ), 65-72. SID. https://sid.ir/paper/371678/en

Vancouver: Copy

Hoshmandi Kiavash, Gooraninejad Saad, HOVEIZI ELHAM, TABANDEH MOHAMMAD REZA. Comparison of Apoptotic Effects of S14161 and Citrus limon Leaves Hydroalcoholic Extracts on Breast Cancer Cells MCF-7. JOURNAL OF DEVELOPMENTAL BIOLOGY[Internet]. 2019;11(1 ):65-72. Available from: https://sid.ir/paper/371678/en

IEEE: Copy

Kiavash Hoshmandi, Saad Gooraninejad, ELHAM HOVEIZI, and MOHAMMAD REZA TABANDEH, “Comparison of Apoptotic Effects of S14161 and Citrus limon Leaves Hydroalcoholic Extracts on Breast Cancer Cells MCF-7,” JOURNAL OF DEVELOPMENTAL BIOLOGY, vol. 11, no. 1 , pp. 65–72, 2019, [Online]. Available: https://sid.ir/paper/371678/en

Related Journal Papers