Analysis of Polymorphisms of Thrombophilia Genes as Risk Factor of Miscarriage: a cross-sectional descriptive study

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SOHRABI AMIR; ESKANDARI FATEMEH; HAJIA MASOUD

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Journal: Iranian Journal of Obstetrics, Gynecology and Infertility Year:2020 | Volume:23 | Issue:4 Page(s): 39-44

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Title

Analysis of Polymorphisms of Thrombophilia Genes as Risk Factor of Miscarriage: a cross-sectional descriptive study

Author(s)

SOHRABI AMIR | ESKANDARI FATEMEH | HAJIA MASOUD | Issue Writer Certificate

Keywords

PolymorphismQ1

Thrombophilia genesQ1

MiscarriageQ1

Abstract

Introduction: Thrombophilia genes are frequently reported to be major risk factors in the development of cardiovascular disease, thromboembolism and more importantly of pregnancy abortion. The study was conducted to investigate the prevalence rate of thrombophilia Polymorphisms in Iranian women. Methods: 591 women had Miscarriage and infertility disorders who were referred to a private pathobiology laboratory in Tehran, Iran. The subjects were evaluated for single nucleotide Polymorphisms using PCR-RFLP procedure during February 2013 to May 2016. Current method was validated and verified for specificity, sensitivity and accuracy by approved and known mutations controls and bioinformatics software’ s. ResultsAt present study, homozygosity of prothrombin (AA), leiden (AA) and HPA-1 (TT) were not diagnosed. Among these genotypes, occurrence of FII (Wild type-GG and heterozygous-GA) was highest and lowest rate as 96. 3% and 3. 7%, respectively. The MTHFR 1298 A>C (AC and CC) had the highest frequency (296 subjects) comparison with the other ones. Outcomes frequency rates (%) of heterozygosity PAI-1, MTHFR1298, MTHFR677, Factor XIII, HPA-1, β-Fibrinogen, Factor V Leiden and Prothrombin were 72. 6 %, 70%, 40. 5%, 29. 4%, 25. 5%, 20%, 4. 4% and 3. 7%, respectively. Conclusion: Heterozygosity prevalence rate of PAI-1, MTHFR1298 and MTHFR677 are the most common in women. It would appear Thrombophilia genes should be considered in preventive strategies particularly in coagulopathy and Miscarriage disorders.

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APA: Copy

SOHRABI, AMIR, ESKANDARI, FATEMEH, & HAJIA, MASOUD. (2020). Analysis of Polymorphisms of Thrombophilia Genes as Risk Factor of Miscarriage: a cross-sectional descriptive study. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, 23(4 ), 39-44. SID. https://sid.ir/paper/371713/en

Vancouver: Copy

SOHRABI AMIR, ESKANDARI FATEMEH, HAJIA MASOUD. Analysis of Polymorphisms of Thrombophilia Genes as Risk Factor of Miscarriage: a cross-sectional descriptive study. IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY[Internet]. 2020;23(4 ):39-44. Available from: https://sid.ir/paper/371713/en

IEEE: Copy

AMIR SOHRABI, FATEMEH ESKANDARI, and MASOUD HAJIA, “Analysis of Polymorphisms of Thrombophilia Genes as Risk Factor of Miscarriage: a cross-sectional descriptive study,” IRANIAN JOURNAL OF OBSTETRICS, GYNECOLOGY AND INFERTILITY, vol. 23, no. 4 , pp. 39–44, 2020, [Online]. Available: https://sid.ir/paper/371713/en

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